Evidence map›Paper›PMID 40534585›Full record

SynthesisPaediatric and perinatal epidemiology2025

Fenton Third-Generation Growth Charts of Preterm Infants Without Abnormal Fetal Growth: A Systematic Review and Meta-Analysis.

Tanis R Fenton, Seham Elmrayed, Belal N Alshaikh

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Paediatric and perinatal epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. NewbornGenes · 2025
    Pooled it
  2. Trial
  3. Comparison of growth and morbidity outcomes in preterm infants using two different intravenous lipid emulsions.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Are premature infants with severe bronchopulmonary dysplasia at increased risk for atypical craniosynostosis?Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Article
  11. Early-life dentine-based elemental biodynamics and cord blood telomere length.medRxiv : the preprint server for health sciences · 2026
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Gut microbiota and short-chain fatty acids in pregnant women with group BFrontiers in cellular and infection microbiology · 2026
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tanis R FentonCommunity Health Sciences, Alberta Children's Hospital Research Institute, O'Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0001-9585-9149
Seham ElmrayedInstitute of Global Health and Human Ecology, American University in Cairo, New Cairo, Egypt.ORCID https://orcid.org/0000-0001-6034-6140
Belal N AlshaikhCommunity Health Sciences, Alberta Children's Hospital Research Institute, O'Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.ORCID https://orcid.org/0000-0002-6080-6888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExperts recommend assessing preterm infant growth against fetal growth patterns. However, obtaining accurate estimates of healthy fetal growth from preterm infants is challenging as many had intrauterine faltering growth.

objectivesTo improve preterm infant growth assessments by developing Fenton third-generation sex-specific preterm growth charts based on anthropometric distributions of preterm infants without abnormal fetal growth. We also aimed to evaluate the consistency of the new charts' growth velocities. DATA SOURCES: From the last search for the 2013 Fenton growth charts to November 2024, MEDLINE and EMBASE databases, grey literature, as well as US Vital statistics and iNeo Consortium. STUDY SELECTION AND DATA EXTRACTION: We followed systematic review methodology to identify population-based sex-specific anthropometric estimates of preterm cohorts without abnormal fetal growth beginning ≤ 24 weeks of gestation. Specified a priori, outcomes included newborn sex-specific estimates of birthweight, length, and head circumference. SYNTHESIS: We followed PRISMA guidelines. Literature screening and quality assessment were performed in duplicate. We harmonised weight, length, and head circumference weighted-average meta-analyses with the World Health Organization growth standard and rescaled the charts' x-axis from completed gestational weeks to exact gestational age (weeks and days).

resultsSeven studies from 15 countries (Australia, Brazil, Canada, China, Finland, Israel, Italy, Japan, Netherlands, New Zealand, Sweden, Switzerland, Spain, United Kingdom and United States) were included, representing 4.8 million births 22-42 weeks of gestation. 174,184 were < 30 weeks gestational age. The Fenton third-generation preterm growth charts' weights showed improved growth velocity across percentiles with consistent declines for weight, length and head circumference velocity as post-menstrual age increased. The birthweight meta-analysis curves had similar shapes to fetal ultrasound estimates.

conclusionsThe Fenton third-generation preterm infant growth chart curves demonstrate improved and more uniform slopes across percentiles and closer alignment with fetal ultrasound estimates, offering a growth standard for preterm infants. PROSPERO REGISTRATION: CRD42024589756.

Indexed as

Fetal DevelopmentGrowth ChartsInfant, PrematureBirth WeightFemaleGestational AgeHumansInfant, NewbornMalefetusgrowthgrowth assessmenthead circumferenceinfantlengthmeta‐analysispreterm birthweight

Identifiers

PMID40534585
PMCPMC12391854

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.