Evidence map›Paper›PMID 40534547›Full record

ArticleCirculation. Heart failure2025

Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy.

Imran R Masood, Lei Wang, Helen M Stanley, Jonathan J Edwards, Humera Ahmed, Kimberly Y Lin, Carol A Wittlieb-Weber, Matthew J O'Connor, Joseph W Rossano, Shannon O'Malley and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Imran R MasoodDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-4803-7657
Lei WangData Science and Biostatistics Unit (L.W., V.W.T.), Children's Hospital of Philadelphia, PA.
Helen M StanleyDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0009-0007-6366-1788
Jonathan J EdwardsDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0002-8153-7066
Humera AhmedDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0002-1572-4840
Kimberly Y LinDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-1582-9797
Carol A Wittlieb-WeberDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.
Matthew J O'ConnorDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-3012-5464
Joseph W RossanoDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0002-8284-0673
Shannon O'MalleyDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.
Stephen M ParidonDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-3330-0598
Vicky W TamData Science and Biostatistics Unit (L.W., V.W.T.), Children's Hospital of Philadelphia, PA.ORCID 0000-0002-4184-992X
Jonathan B EdelsonDivision of Cardiology (I.R.M., H.M.S., J.J.E., H.A., K.Y.L., C.A.W.-W., M.J.O., J.W.R., S.O., S.M.P., J.B.E.), Children's Hospital of Philadelphia, PA.ORCID 0000-0003-3220-7922

Funding

MIGHTIER: Movement in Heart Transplant patients: the Impact of Environmental factoRsK23HL169833 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Jonathan Buniva Edelson · 2024 to 2026
$482k
NHLBI NIH HHS K23 HL169833
6 · The paper itself

Abstract

backgroundRestricting certain patients with hypertrophic cardiomyopathy (HCM) from exercise likely has negative cardiovascular effects and has not been shown to reduce the risk of sudden cardiac death. Promoting exercise in children with HCM is complex and requires knowledge of the environmental factors that impact exercise capacity in children with HCM.

methodsThis retrospective, cross-sectional analysis includes children with HCM who underwent exercise stress testing at a single, children's tertiary-care center between 2000 and 2023. Addresses from contemporaneous exercise stress testing were accessed and geocoded to census tracts. The child opportunity index was the primary exposure of interest. Granular neighborhood measures including the walkability index, rural-urban commuting area codes, index of concentration at the extremes, and uniform crime reporting rates were measured. The primary outcome measure was peak oxygen consumption. Linear regression and multivariable analyses were performed.

resultsA total of 155 patients were identified who met inclusion criteria, 23% (n=35) of whom were female. The mean age at the time of exercise stress testing was 15.8±3.1 years. More than half of the included patients were from a high or very high child opportunity index (30%, n=46, and 35%, n=54, respectively). Most patients lived in urban environments (rural-urban commuting area codes score, 1 or 2, 96.7%, n=150). The mean peak oxygen consumption was 2159±906 mm/min, and the adjusted peak oxygen consumption was 35.5±9.3 mL/kg per min. A multivariate model adjusting for disease severity, age at diagnosis of HCM, race, and accounting for collinearity showed that low child opportunity index, higher levels of urbanization, and lower concentration of neighborhood wealth were independently associated with lower peak oxygen consumption.

conclusionsOur study identified previously unrecognized environmental determinants of exercise capacity in children with HCM, with lower child opportunity index, increased urbanization, and lower neighborhood wealth independently associated with lower exercise performance. Programs designed to increase physical activity levels and exercise performance in children with HCM should account for neighborhood and economic factors.

Indexed as

Cardiomyopathy, HypertrophicExercise ToleranceNeighborhood CharacteristicsResidence CharacteristicsAdolescentChildCross-Sectional StudiesExercise TestFemaleHumansMaleOxygen ConsumptionRetrospective Studiesbuilt environmentcardiac rehabilitationcardiomyopathy, hypertrophicexercise testmental health

Identifiers

PMID40534547
PMCPMC13312501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.