Evidence map›Paper›PMID 40534539›Full record

ArticleJournal of clinical and experimental neuropsychology

Brooding rumination predicts lower cognitive functioning in late-life depression: multivariate multiple regression analyses.

Kiara Baker, Warren D Taylor, Sarah M Szymkowicz

Abstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kiara BakerCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Warren D TaylorCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah M SzymkowiczCenter for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
1/3-Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-life Depression (Rembrandt)R01MH121620 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAYLOR, WARREN D · 2020 to 2024
$5.3M
Neural Connectivity Affecting the Antidepressant Response: Testing a Lesion ModelR01MH102246 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAYLOR, WARREN D · 2015 to 2019
$3.1M
Frontal hypo perfusion effects on antidepressant outcomes in geriatric depressionR21MH099218 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAYLOR, WARREN D · 2013 to 2014
$429k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NIMH NIH HHS R01 MH102246NIMH NIH HHS R01 MH121620NIMH NIH HHS R21 MH099218
6 · The paper itself

Abstract

introductionLate-life depression (LLD) is associated with cognitive deficits, particularly in memory and executive functions. Rumination, namely brooding, may also negatively impact cognition. Few studies have investigated multivariate relationships between depressive symptoms and different types of rumination on cognition in LLD, which was the focus of the current study. We also explored whether relationships differed by gender and depression age of onset.

methodCognition was measured via five cognitive composites (Attention/Working Memory, Processing Speed, Language, Episodic Recall, and Executive Functions). LLD who completed both the Montgomery Asberg Depression Rating Scale (MADRS) and Ruminative Responses Scale (RRS) was used in analyses (

resultsOnly Brooding significantly predicted cognitive performance in the multivariate omnibus models (

conclusionElevated Brooding (and not depressive symptoms, Reflection rumination, or their interactions) was associated with lower language and memory functions in LLD. This effect may be greater in women, particularly for memory. Interventions aimed at improving brooding rumination in LLD may also benefit cognitive performance.

Indexed as

Cognition DisordersDepressionRumination, CognitiveAgedAged, 80 and overAge of OnsetExecutive FunctionFemaleHumansMaleMiddle AgedMultivariate AnalysisNeuropsychological TestsPsychiatric Status Rating ScalesRegression AnalysisSex FactorsagingCognitiondepressiongeriatricneuropsychological testingrepetitive negative thinking

Identifiers

PMID40534539
PMCPMC12354303

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.