Evidence map›Paper›PMID 40534408›Full record

ArticleRenal failure2025

Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.

Si Yi, Feiyan Li, Xin Ma, Yao Xu, Weijing Lai, Hongxi Chen, Junming Fan, Nan Mao, Sichong Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Si YiDepartment of Nephrology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
Feiyan LiClinical Medical College of Chengdu Medical College, Chengdu, China.
Xin MaClinical Medical College of Chengdu Medical College, Chengdu, China.
Yao XuClinical Medical College of Chengdu Medical College, Chengdu, China.
Weijing LaiClinical Medical College of Chengdu Medical College, Chengdu, China.
Hongxi ChenClinical Medical College of Chengdu Medical College, Chengdu, China.
Junming FanClinical Medical College of Chengdu Medical College, Chengdu, China.ORCID 0000-0003-2213-4782
Nan MaoClinical Medical College of Chengdu Medical College, Chengdu, China.
Sichong RenClinical Medical College of Chengdu Medical College, Chengdu, China.ORCID 0000-0001-7311-4314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is a key pathological process in the progression of chronic kidney disease (CKD). Panaxatriol saponins (PTS), the main bioactive compounds extracted from

Indexed as

GinsenosidesKidneyRenal Insufficiency, ChronicSaponinsAnimalsDisease Models, AnimalFibrosisInflammationMaleMolecular Docking SimulationRatsRats, Sprague-DawleySignal TransductionSmad3 ProteinTransforming Growth Factor beta1Tumor Necrosis Factor-alphaGinsenosidespanaxatriolSaponinsSmad3 ProteinSmad3 protein, ratTgfb1 protein, ratTransforming Growth Factor beta1Tumor Necrosis Factor-alphachronic kidney diseasePanaxatriol saponinsrenal fibrosisTGF-β1/smad3TNF-αUUO model

Identifiers

PMID40534408
PMCPMC12180341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.