Trial reportBrain and behavior2025
A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End-Stage Renal Disease Undergoing Dialysis.
Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
Funding
Abstract
introductionEnd-stage renal disease (ESRD) is a severe condition that necessitates dialysis. Dialysis treatments, including hemodialysis and peritoneal dialysis, can affect various organs, including the brain, leading to potential cognitive decline. This study investigates the neurological effects and brain network reorganization in ESRD patients undergoing different dialysis methods.
methodsA total of 120 ESRD patients were randomly divided into two groups: 60 patients undergoing hemodialysis and 60 undergoing peritoneal dialysis. Patients were followed for 1 year. Neuropsychological scales assessed cognitive function, and MRI scans were used to analyze brain structure and functional network dynamics before and after dialysis. Laboratory indicators and clinical outcomes were also recorded.
resultsBoth dialysis methods improved renal function, but peritoneal dialysis showed more favorable effects on cognitive function, with higher MMSE and MOCA scores. MRI analysis revealed better functional brain network efficiency in the peritoneal dialysis group. No significant differences were observed in the incidence of complications between the two groups.
conclusionAlthough hemodialysis showed better renal function outcomes, peritoneal dialysis was associated with better cognitive performance and brain network reorganization. Both methods were safe, but peritoneal dialysis may offer neuroprotective benefits over hemodialysis in ESRD patients.
trial registrationNational Health Insurance Medical Research Registration and Filing Information System: MR-46-22-012452.
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