Evidence map›Paper›PMID 40534223›Full record

SynthesisBrain and behavior2025

Association Between Handgrip Strength and Suicidal Ideation: A Systematic Review and Meta-Analysis.

Prakasini Satapathy, Abhay M Gaidhane, Nasir Vadia, Soumya V Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Manpreet Kaur, Ganesh Bushi, Muhammed Shabil, Diptismita Jena and 5 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Prakasini SatapathyCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Abhay M GaidhaneJawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education, Wardha, India.
Nasir VadiaMarwadi University Research Center, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Rajkot, Gujarat, India.
Soumya V MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Kattela ChennakesavuluDepartment of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Rajashree PanigrahiDepartment of Microbiology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Manpreet KaurDepartment of Pharmacy, Chandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, India.
Ganesh BushiChitkara Centre for Research and Development, Chitkara University, Rajpura, Punjab, India.
Muhammed ShabilUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Diptismita JenaCentre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India.
Mayank GoyalIES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India.
Harish KumarNew Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India.
Anju RaniDepartment of Microbiology, Graphic Era (Deemed to be University), Dehradun, India.
Sanjit SahSR Sanjeevani Hospital, Kalyanpur, Siraha, Nepal.ORCID https://orcid.org/0009-0008-5017-083X
Khang Wen GohFaculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuicidal ideation is a global public health concern, highlighting the need to identify modifiable risk factors. Handgrip strength (HGS), an objective measure of muscular strength, has been linked to mental health outcomes. This review synthesizes evidence on HGS and suicidal ideation, exploring modifiers such as sex.

methodsThis systematic review and meta-analysis, registered with PROSPERO and conducted in accordance with PRISMA guidelines, evaluated data retrieved from PubMed, Embase, and Web of Science up to November 30, 2024. The analysis focused on randomized controlled trials and observational studies-including case-control, cohort, and cross-sectional designs-that examined the relationship between HGS and suicidal ideation in human populations. A random-effects model was employed to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I

resultsOut of 294 studies, 9 met the inclusion criteria for the systematic review, and 6 were eligible for meta-analysis, involving 81,035 participants. The pooled analysis showed a nonsignificant association between HGS and suicidal ideation. For males, the pooled OR per 1 kg increase in HGS was 0.939 (95% CI, 0.875-1.009), and for females, it was 0.851 (95% CI, 0.662-1.094), indicating a potential but nonsignificant protective effect.

conclusionThis systematic review and meta-analysis found no statistically significant association between handgrip strength and suicidal ideation in the pooled analysis. However, consistent trends observed in the qualitative synthesis suggest a potential relationship that warrants further investigation. Longitudinal studies are essential to elucidate the underlying mechanisms.

Indexed as

Hand StrengthSuicidal IdeationFemaleHumansMaleRisk FactorsHandgrip strengthmental healthmeta‐analysissuicidal ideationsystematic review

Identifiers

PMID40534223
PMCPMC12177198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.