Evidence map›Paper›PMID 40534189›Full record

ArticlePhysiological reports2025

Assessment of ventilation heterogeneity in severe asthma using phase-resolved functional lung magnetic resonance imaging.

Chuan T Foo, David Langton, Graham M Donovan, Bruce R Thompson, Peter B Noble, Francis Thien

Abstract read
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. From FEVJournal of asthma and allergy · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chuan T FooFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-1497-9830
David LangtonFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
Graham M DonovanDepartment of Mathematics, University of Auckland, Auckland, New Zealand.
Bruce R ThompsonSchool of Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.
Peter B NobleSchool of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Francis ThienFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1180854MU | Faculty of Medicine, Nursing and Health Sciences, Monash University
6 · The paper itself

Abstract

Ventilation heterogeneity is a hallmark of asthma. This study examines the feasibility of phase-resolved functional lung magnetic resonance imaging (PREFUL MRI) in the evaluation of ventilation heterogeneity in severe asthma, its response to bronchodilator, and correlation with spirometry. Twenty-three patients with severe asthma and seven healthy volunteers completed PREFUL MRI and spirometry pre and post-bronchodilator. Ventilation heterogeneity was assessed using ventilation defect percentages (VDP) for regional ventilation (RVent) and flow-volume loop cross-correlation (FVL), interquartile distance (IQD), and inhomogeneity index (IHI). Patients exhibited a significantly higher pre-bronchodilator VDP

Indexed as

AsthmaLungMagnetic Resonance ImagingPulmonary VentilationAdultBronchodilator AgentsFemaleHumansMaleMiddle AgedSpirometryBronchodilator Agentsasthmafunctional lung imaginglung physiologymagnetic resonance imagingventilation heterogeneity

Identifiers

PMID40534189
PMCPMC12177108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.