ArticleJournal of health, population, and nutrition2025
Epidemiological trends and burden of metabolic dysfunction-associated steatotic liver disease in the Middle East and North Africa region: a 32-year analysis of health impact.
Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Increased global burden of metabolic dysfunction-associated steatotic liver disease is also seen in women of reproductive age.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Dietary Fat Intake and Its Influence on the Association Between Liver Fat and Brain Choline Metabolism in Young Saudi Women.Saudi medical journal · 2026Article
- Metabolic and Lifestyle Profiles of Metabolic Dysfunction-Associated Steatotic Liver Disease in Romanian and Italian Adults.Medicina (Kaunas, Lithuania) · 2026Observational
- Risk Factors for Dysfunctional Liver Graft Response: A Case-Control Study.Nursing & health sciences · 2026Article
- Composite dietary antioxidant index and risk of metabolic dysfunction - associated steatotic liver disease: evidence from a prospective cohort study.Nutrition & metabolism · 2026Article
- Knowledge and Determinants of Nonalcoholic Fatty Liver Disease Among Adults in Northern Border Region, Saudi Arabia: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2026Article
- Article
- Association of serum uric acid and serum uric acid/creatinine ratio with metabolic dysfunction-associated fatty liver disease in young adults: a retrospective study.BMC endocrine disorders · 2026Article
- Clinical biomarkers and biosensors for early detection of metabolic dysfunction-associated steatohepatitis (MASH): a translational perspective.Frontiers in bioengineering and biotechnology · 2026Review
- Divergent Trajectories of the Burden of MASLD Attributable to High Fasting Plasma Glucose in China and Globally: A GBD Study 1990-2021 and Projections to 2046.Gastroenterology research and practice · 2026Article
- Metabolic dysfunction-associated steatotic liver disease in Egypt: Epidemiology, risk factors and management challenges.World journal of gastroenterology · 2025Review
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Authors and funding
13 authors.
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Abstract
backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is a condition marked by excess liver fat, ranging from simple steatosis to non-alcoholic steatohepatitis. Updated reports on the epidemiology of MASLD in the Middle East and North Africa (MENA) region are needed. This study aimed to report the trends in the MASLD burden in the MENA region from 1990 to 2021, as well as age and sex patterns and their association with the sociodemographic index (SDI).
methodsData on the incidence, prevalence, disability-adjusted life years (DALYs), and mortality of MASLD in 21 countries within the MENA region from 1990 to 2021 were extracted from the GBD 2021 study. The relationship with the SDI and the burden attributable to risk factors, such as high fasting plasma glucose and smoking, were examined.
resultsBetween 1990 and 2021, the MENA region experienced a 13.8% increase in the age-standardized incidence rate, reaching 1,037.6 per 100,000 population. The age-standardized prevalence saw a rise of 26.4%. Women experienced a higher increase in incidence than men. The highest rates of DALYs were observed among older adults. Countries with a high SDI faced a greater disease burden. High fasting plasma glucose accounted for the largest burden of MASLD.
conclusionsThe study found that the incidence and prevalence of MASLD in the MENA region increased significantly from 1990 to 2021, especially in areas with high SDI. High fasting plasma glucose was the most significant attributable risk factor, highlighting the need for metabolic interventions. CLINICAL TRIAL NUMBER: Not applicable.
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