Evidence map›Paper›PMID 40533810›Full record

ArticleNutrition & metabolism2025

The effect of multiple micronutrients supplementation on preventing anemia during pregnancy: a retrospective cohort study.

Junhui Zhong, Nan Li, Junxi Chen, Jufen Liu, Zhiwen Li, Jiamei Wang, Xiaohong Liu

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Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Junhui ZhongInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing, 100191, China.
Nan LiInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing, 100191, China.
Junxi ChenInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing, 100191, China.
Jufen LiuInstitute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing, 100191, China.
Zhiwen Li *Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University, Beijing, 100191, China. lizw@bjmu.edu.cn.
Jiamei WangDepartment of Obstetrics and Gynecology, Haidian Maternal & Child Health Hospital, Beijing, 100080, China.
Xiaohong Liu *Department of Obstetrics and Gynecology, Haidian Maternal & Child Health Hospital, Beijing, 100080, China. 13522099566@163.com.

Funding

Key Project of the Regional Innovation and Development Joint Fund of the National Natural Science Foundation of China U23A20420National Natural Science Foundation of China 82373582
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of Multiple Micronutrient (MMN) Supplements during pregnancy in reducing the risk of anemia among pregnant women.

methodA retrospective cohort study was conducted with the supplement of Folic Acid (FA) only and FA plus MMN groups. Data was collected through questionnaires during the first prenatal visit. Hemoglobin levels were extracted from the Laboratory Information System. A total of 4,239 pregnant women who were admitted to Beijing Haidian Maternal & Child Health Hospital between May 2017 and November 2020 was evaluated. Chi-square tests and log-binomial regression were conducted to evaluate the relative risks (RRs) of two groups on the reduction of anemia during pregnancy.

resultsThe supplement of MMN was found to significantly decrease the risk of anemia in the later stages of pregnancy. Focusing on the third trimester specifically, the crude RR and adjusted RR were 0.891 and 0.844 respectively. In the second and third trimester of pregnancy, a sufficient monthly intake frequency of MMN(≥ 24 pills) is associated with a lower relative risk of anemia, with a value of 0.897 and 0.809 compared to the group supplement FA only.

conclusionsThe supplement of MMN has been correlated with a reduced risk of anemia in the second and third trimesters of pregnancy. But the efficacy was limited in the first trimester. Frequent and early initiation of supplementation with FA and MMN pills is associated with a more significant reduction in the risk of anemia compare to group supplement of FA only.

Indexed as

Anemia during pregnancyFolic acidMultiple micronutrientsRetrospective cohort study

Identifiers

PMID40533810
PMCPMC12177998

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