Trial reportJournal of neuroengineering and rehabilitation2025
Neural mechanisms underlying the improvement of gait disturbances in stroke patients through robot-assisted gait training based on QEEG and fNIRS: a randomized controlled study.
Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07057700 (Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Mechanisms of Welwalk Robot in Restoring Motor Function of the Lower Extremities in Stroke Patients
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Post-stroke lower limb rehabilitation: a comparative study between exoskeleton robots and traditional gait training.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Robotic Training and Neural Reorganization in Stroke: A Systematic Review.F1000Research · 2026Pooled it
- Robot-assisted gait training in people with subacute and chronic stroke: a randomized controlled trial.Frontiers in neurology · 2026Trial
- Trial
- Effect of robot-assisted gait training combined with electroacupuncture on lower limb motor function and brain network characteristics in stroke: an EEG study.Journal of neuroengineering and rehabilitation · 2025Trial
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions.Bioengineering (Basel, Switzerland) · 2026Review
- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Core muscle rehabilitation during early mobilization after stroke: a narrative review and clinical framework.Frontiers in neurologyReview
- A review of the impact of circadian rhythm on motor function in stroke recovery patients.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundRobot-assisted gait training is more effective in improving lower limb function and walking ability in stroke patients compared to conventional rehabilitation, but the neural mechanisms remain unclear. This study aims to explore the effects of robot-assisted gait training on lower limb motor dysfunction in stroke patients and its impact on neural activity in the motor cortex, providing objective evidence for clinical application.
methodsForty-two stroke patients meeting the inclusion criteria were randomly assigned to either the experimental group receiving robot-assisted gait training or the control group receiving conventional overground walking training. Assessments were conducted at baseline and after four weeks of treatment. Primary outcome measures included cortical activation measured by functional near-infrared spectroscopy (fNIRS), power ratio index (PRI), and delta/alpha power ratio (DAR) measured by quantitative electroencephalography (QEEG), and their correlation with the Fugl-Meyer Assessment (FMA) for lower limb motor function. Secondary outcome measures included FMA and Functional Ambulation Category (FAC).
resultsData from 36 patients (18 in each group) after four weeks of treatment were analyzed. The fNIRS results indicated better activation in the premotor and supplementary motor cortices in the robot-assisted gait training group compared to the control group. QEEG analysis showed reduced PRI and DAR in the premotor, supplementary motor, and primary motor cortices in the robot-assisted gait training group, suggesting improved motor function recovery in stroke patients. Clinical scale analysis revealed superior motor function recovery in the robot-assisted gait training group compared to the control group.
conclusionsRobot-assisted gait training significantly enhances activation in the primary motor cortex and supplementary motor area, potentially aiding stroke patients in recovering their ability to plan. PRI and DAR, particularly PRI, are valuable clinical indicators for assessing motor function recovery in stroke patients.
trial registrationChinese Clinical Trial Registry (ChiCTR2200060668). Registered on June 6, 2022; https://www.chictr.org.cn/showproj.html?proj=171610 .
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