ArticleJournal of orthopaedic surgery and research2025
MiR-217 participates in the progression of postmenopausal osteoporosis by regulating the OPG/RANKL/RANK pathway.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- miR-211-5p/FOXO3 axis accelerates osteogenic differentiation and fracture healing by mediating Wnt/β-catenin pathway.Journal of orthopaedic surgery and research · 2026Article
- The clinical role of lncRNA PRKG1-AS1 in lumbar disc degeneration and its mechanism in regulating inflammation and ferroptosis via miR-218-5p.Journal of orthopaedic surgery and research · 2026Article
- Long non-coding RNA CKMT2-AS1 serves as a biomarker for osteoarthritis and participates in chondrocyte injury via miR-6720-5p.Journal of orthopaedic surgery and research · 2026Article
- HECTD4 in human umbilical cord mesenchymal stem cells-derived exosomes alleviates osteoclast differentiation in osteoporosis progression by suppressing RANK m6A modification via promoting METTL3 ubiquitination.Journal of molecular histology · 2026Article
- Dexmedetomidine mitigates postoperative delirium after hip fracture surgery in elderly patients by modulating miR-107 expression.Journal of orthopaedic surgery and research · 2026Article
- LncRNA GAS5 inhibits the remodeling of the tumor microenvironment by binding to miR-93-5p, thereby suppressing the development of osteosarcoma.Journal of orthopaedic surgery and research · 2026Article
- Study on the pro-inflammatory mechanism mediated by the RANK-SPP1 axis in macrophage immunomodulation during atherosclerosis.Molecular and cellular biochemistry · 2026Article
- circ_0044235 exacerbates neuroinflammation and apoptosis following spinal cord injury by targeting miR-338-5p.Journal of orthopaedic surgery and research · 2026Article
- Inhibition of miR-224-5p promotes osteogenesis in dental pulp stem cells by targeting the PTEN/PI3K/AKT axis.Journal of orthopaedic surgery and research · 2026Article
- Clinical significance and regulatory mechanism of miR-4284 in lumbar intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2026Article
- Long non-coding RNA LINC-PINT: emerging clinical significance and molecular mechanisms in knee osteoarthritis.Journal of orthopaedic surgery and research · 2026Article
- piR-27222 alleviates dexamethasone-induced osteoporosis by inhibiting ferroptosis through modulating WWP1.Journal of orthopaedic surgery and research · 2026Article
- The expression characteristics of miR-206-3p in musculoskeletal tissue and its clinical significance.Journal of orthopaedic surgery and research · 2026Article
- Mesenchymal stem cell-derived miR-125b-1-3p-abundant exosomes alleviate osteoarthritis by modulating the KDM6B-H3K27me3-FOXM1 axis.Journal of orthopaedic surgery and research · 2026Article
- miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A.Journal of orthopaedic surgery and research · 2026Article
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3 authors.
Funding
Abstract
backgroundMicroRNAs regulate the OPG/RANKL/RANK signaling pathway, which is crucial for postmenopausal osteoporosis (PMO) development. Explore the role of miR-217 in PMO by regulating the OPG/RANKL/RANK signaling pathway.
methodsTaking osteoblast MC3T3-E1 as the research object, PMO model rats were further constructed. Reverse transcription quantitative PCR was used to detect the expression of miR-217 and related genes in cells and rat serum. Western blotting was used to detect the expression of relevant proteins. Enzyme-linked immunosorbent assay was used to detect the levels of related indicators in the serum of model rats.
resultsWith the osteogenic differentiation of MC3T3-E1 cells, the relative expression level of miR-217 gradually decreases. Overexpression of miR-217 inhibits cell proliferation and osteogenic differentiation, while promoting cell apoptosis. Conversely, the knockdown of miR-217 elicited opposite outcomes. miR-217 was demonstrated to target OPG and thereby influence MC3T3 - E1 cells, with potential involvement of the OPG/RANKL/RANK signaling pathway. Additionally, the expression of miR-217 in the serum of rats with the PMO model was upregulated. Conversely, the inhibition of miR-217 demonstrated the capacity to augment bone metabolism and osteogenic differentiation in these model rats. Additionally, miR-217 was found to specifically target OPG. Knockdown of miR-217 upregulates OPG, inhibits RANKL-RANK interaction, and suppresses the NF-κB/MAPK pathways.
conclusionsThe expression of miR-217 is upregulated in PMO, and it may participate in the progression of the disease by regulating the OPG/RANKL/RANK signaling pathway.
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