Evidence map›Paper›PMID 40533775›Full record

ArticleFluids and barriers of the CNS2025

Deformation of brain in normal pressure hydrocephalus is more readily associated with slow vasomotion rather than heartbeat related pulsations of intracranial pressure.

Ronald T Murambi, Henora Chour, Magdalena Kasprowicz, Craig R Vonhoff, Marek Czosnyka, Zofia Czosnyka, Matthias Jaeger

Abstract read
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In one paragraph

Article in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ronald T Murambi *Department of Neurosurgery, Wollongong Hospital, Loftus Street, Wollongong, NSW, 2500, Australia.
Henora ChourDepartment of Medical Imaging, Wollongong Hospital, Wollongong, NSW, Australia.
Magdalena KasprowiczDepartment of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland.
Craig R VonhoffDepartment of Neurosurgery, Wollongong Hospital, Loftus Street, Wollongong, NSW, 2500, Australia.
Marek CzosnykaDepartment of Clinical Neurosciences, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
Zofia CzosnykaDepartment of Clinical Neurosciences, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.
Matthias Jaeger *Department of Neurosurgery, Wollongong Hospital, Loftus Street, Wollongong, NSW, 2500, Australia. matthias.jaeger@health.nsw.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEnlarged brain ventricles, compressed parasagittal cerebrospinal fluid spaces, steep callosal angle, dilated sylvian fissures and focal cortical sulcal dilatation are typical imaging features of idiopathic normal pressure hydrocephalus (iNPH). The pathophysiological mechanisms behind these morphological changes are poorly understood, but the hydrodynamic concepts of communicating hydrocephalus suggest that increased heartbeat related intracranial pulsations are involved in ventricular enlargement. In this cross-sectional study we analysed the association between the radiological findings of iNPH and the physiological intracranial pressure (ICP) waveform components.

methods117 patients with suspected iNPH underwent computerised overnight ICP monitoring with calculation of heartbeat related ICP pulse wave amplitude (calculated in the frequency domain, AMP, and time domain, MWA), amplitude of respiration induced ICP waves (RESP), power of slow vasogenic waves (SLOW), and index of cerebrospinal compensatory reserve (RAP). Radiological morphological data was recorded from computed tomography using Evans Index (EI), frontal occipital horn ratio (FOHR), and disproportionately enlarged subarachnoid space hydrocephalus (DESH) score.

resultsThe strongest correlation was observed between SLOW and DESH (r = 0.44, p < 0.012). SLOW also correlated with ventricular size as measured with EI (r = 0.23, p = 0.045) and FOHR (r = 0.26, p = 0.037). ICP and RESP also correlated with DESH (r = 0.25, p = 0.037 and r = 0.25, p = 0.038, respectively). AMP and MWA were not correlated with the radiological data.

conclusionsMainly SLOW showed correlations with the morphological imaging features of iNPH. SLOW is influenced by vasomotion and intracranial compliance. This study suggests that the magnitude of ICP slow wave activity, but not ICP pulse component is related to the size of brain ventricles and DESH in iNPH.

Indexed as

BrainHeart RateHydrocephalus, Normal PressureIntracranial PressureAgedAged, 80 and overCerebral VentriclesCross-Sectional StudiesFemaleHumansMaleMiddle AgedTomography, X-Ray ComputedComputed tomographyIdiopathic normal pressure hydrocephalusIntracranial complianceIntracranial pressureIntracranial pulsationsNeuromonitoring

Identifiers

PMID40533775
PMCPMC12175371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.