ArticleWorld journal of surgical oncology2025
Increased GPR35 expression is correlated with poor prognosis in prostate cancer.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The role of lysophosphatidic acid metabolism in castration-resistant prostate cancer progression.Frontiers in oncology · 2026Review
- G protein-coupled receptors in prostate cancer: research progress and therapeutic targets.Frontiers in cell and developmental biology · 2025Review
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14 authors.
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Abstract
backgroundG-protein-coupled receptor 35 (GPR35) has been reported to be overexpressed in several types of human cancers, playing essential roles in tumorigenesis and development. However, its expression and prognostic value in Prostate cancer (PCa) remain unclear. This study aims to investigate the expression of GPR35 and its prognostic value in PCa.
methodsThe expression of GPR35 was analyzed using the public database and validated by immunohistochemistry (IHC) in PCa tissues. Subsequently, the correlation between GPR35 expression and the clinical characteristics was evaluated using the Chi-squared test. Kaplan-Meier and Cox proportional hazards regression models were used to analyze the data. Hazard Ratios (HR) and 95% confidence intervals (CI) were calculated for each factor.
resultsGPR35 messenger RNA (mRNA) and protein expression were confirmed to be overexpressed in PCa tissue samples. Furthermore, high GPR35 mRNA expression was correlated with clinical tumor stage (T stage) (P < 0.001), lymph node metastasis (P < 0.001), primary therapy outcome (P = 0.009), residual tumor (P < 0.001), prostate-specific antigen (PSA) levels (P = 0.004), and Gleason score (P < 0.001). IHC analysis also confirmed that GPR35 overexpression was associated with lymph node metastasis (P = 0.010). Additionally, Kaplan-Meier analysis showed that PCa patients with high expression of GPR35 were associated with shorter overall survival (OS) (HR: 3.370, 95% CI: 1.085-10.470, P = 0.047), progress free interval (PFI) (HR: 3.385, 95% CI: 2.234-5.131, P < 0.001), and biochemical relapse time (BCR) (HR: 2.229, 95% CI: 1.308-3.801, P = 0.007). Moreover, univariate Cox regression analyses suggested that T stage (P < 0.001), lymph node involvement (P = 0.046), serum PSA levels (P = 0.013), Gleason score (P < 0.001), and GPR35 expression (P < 0.001) were unfavorable prognostic factors for PCA patients. Multivariate Cox regression analysis showed that GPR35 was an independent poor prognostic factor of PCa patients (HR: 1.915, 95%CI: 1.368-2.682).
conclusionOverexpression of GPR35 is associated with poor clinical prognosis, suggesting that GPR35 may serve as a potential prognostic biomarker for PCa. CLINICAL TRIAL NUMBER: Not applicable.
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