Evidence map›Paper›PMID 40533741›Full record

ArticleHarm reduction journal2025

"To not feel fake, it can't be fake": co-creation of a harm reduction, peer-delivered, health-system intervention for people who use drugs.

J Deanna Wilson, Stephanie P Klipp, Kelsey Leon, Jane M Liebschutz, Jessica Merlin, Cristina Murray-Krezan, Sommer Nolette, Kristina T Phillips, Michael Stein, Nate Weinstock and 1 more

Abstract read
In one paragraph

Article in Harm reduction journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J Deanna WilsonDepartment of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, 51 N 39th Street, Philadelphia, PA, 19104, USA. Jacqueline.wilson1@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8400-9958
Stephanie P KlippPrevention Point, Philadelphia, PA, USA.
Kelsey LeonDepartment of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, 51 N 39th Street, Philadelphia, PA, 19104, USA.
Jane M LiebschutzDivision of General Internal Medicine, Center for Research On Healthcare, University of Pittsburgh, Pittsburgh, PA, USA.
Jessica MerlinDivision of General Internal Medicine, Center for Research On Healthcare, University of Pittsburgh, Pittsburgh, PA, USA.
Cristina Murray-KrezanDivision of General Internal Medicine, Center for Research On Healthcare, University of Pittsburgh, Pittsburgh, PA, USA.
Sommer NolettePregnancy Recovery Center, UPMC, Pittsburgh, PA, USA.
Kristina T PhillipsCenter for Integrated Health Care Research, Kaiser Permanente Hawaii, Honolulu, HI, USA.
Michael SteinDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, MA, USA.
Nate WeinstockDivision of General Internal Medicine, Center for Research On Healthcare, University of Pittsburgh, Pittsburgh, PA, USA.
Megan HammCenter for Biostatistics and Qualitative Methodology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
THRIVE: Teaching Health promotion and Resilience in Varied Environments: a peer-led intervention following hospital dischargeR01DA057633 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jacqueline Deanna Wilson · 2022 to 2026
$3.8M
Treatment of Opioid Use Disorder in Young Adults Hospitalized with Infectious Complications of Injection Opioid UseK23DA048987 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILSON, JACQUELINE DEANNA · 2020 to 2022
$570k
NIDA NIH HHS K23 DA048987NIDA NIH HHS R01 DA057633NIDA NIH HHS R01DA057633NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

backgroundPeople who use drugs (PWUD) continue to experience not only high overdose rates but also growing infectious complications. In response, there has been a growing focus on increasing access to harm reduction resources, particularly among hospitalized PWUD. However, there is limited data on how best to integrate harm reduction into hospital settings. We describe using a Design Sprint, a human-centered design process, to co-create an intervention with people who have lived experience (PWLE) focused on improving access and adoption of harm reduction behaviors for hospitalized PWUD.

methodsWe recruited a sample of PWLE from Pittsburgh, Pennsylvania. We recruited a total of 14 participants over a 3-week period from March to April 2024. There were four Design Sprint sessions, two-hours in length, delivered via HIPAA-compliant zoom. Participants identified intervention components, sketched the intervention, and prototyped the planned intervention process. Sessions were recorded and transcribed verbatim. The team identified intervention components and key themes using thematic analysis.

resultsThere were 14 PWLE (mean age 40.4 years; majority white) who participated in at least one Design Sprint session. Participants conceptualized an intervention delivered by a THRIVE navigator who establishes rapport, identifies what if any goals the participant may have, offers information from a menu of harm reduction topics, and helps participants create a Wellness Plan focused on achieving their goals and overcoming likely barriers. The THRIVE navigator will then follow-up via weekly text messages. There were four additional themes that informed intervention content and implementation. These were related to the hospital being experienced as a hostile environment to PWUD; the value of health information being delivered by PWLE who can speak authentically; the importance of creating a flexible participant-led intervention offering a range of content; and the importance of neutrality to building authenticity and attaining participant buy-in.

conclusionsThe Design Sprint process allowed for rich input from PWLE on the design, scope, content, and implementation of the THRIVE intervention. Findings highlight the importance of a peer navigator role to embody relational harm reduction and guide THRIVE participants in education and goal setting around a host of wellness-related behaviors.

Indexed as

Drug UsersHarm ReductionPeer GroupSubstance-Related DisordersAdultFemaleHumansMaleMiddle AgedPennsylvania

Identifiers

PMID40533741
PMCPMC12175332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.