Evidence map›Paper›PMID 40533694›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

457 nm LED blue light inhibits oral squamous cell carcinoma cell proliferation via the PI3K/AKT pathway and autophagy.

Hui Jiang, Jiali Yang, Qiqi Fu, Haokuan Qin, Muqing Liu

Abstract read
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In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui JiangAcademy for Engineering and Technology, Fudan University, 220Th Handan Road, Shanghai, 200433, China.
Jiali YangSchool of Information Science and Technology, Fudan University, 2005Th Songhu Road, Shanghai, 200438, China.
Qiqi FuSchool of Information Science and Technology, Fudan University, 2005Th Songhu Road, Shanghai, 200438, China.
Haokuan QinAcademy for Engineering and Technology, Fudan University, 220Th Handan Road, Shanghai, 200433, China.
Muqing LiuSchool of Information Science and Technology, Fudan University, 2005Th Songhu Road, Shanghai, 200438, China. mqliu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-6057-4960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhotobiomodulation (PBM) therapy, utilizing light to regulate cellular processes, holds promise as a cancer treatment. We aimed to explore PBM's impact on two oral squamous cell carcinoma (OSCC) cell lines, Cal-27 and SCC-25, under varying blue light irradiation conditions.

methodsCal-27 and SCC-25 cells were exposed to 457 nm blue light at varying irradiances (2.5-70 mW/cm

results457 nm blue light significantly reduced OSCC cell viability, with efficacy increasing proportionally to radiant exposure. This effect resulted primarily from inhibited cell proliferation, as we observed no significant apoptosis or necrosis. Additionally, blue light elevated reactive oxygen species levels in OSCC cells while selectively decreasing mitochondrial membrane potential in SCC-25 cells, suggesting variable cell-type responses. Besides, autophagy levels were modulated by blue light exposure.

conclusionThe study demonstrates that 457 nm blue LED photobiomodulation therapy inhibits OSCC cell progression by promoting autophagy and inhibiting PI3K/AKT pathway-mediated cell proliferation. These insights provide a basis for exploring therapeutic applications of photobiomodulation in oral cancer treatment.

Indexed as

AutophagyCarcinoma, Squamous CellLightMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktApoptosisBlue LightCell Line, TumorCell ProliferationCell SurvivalHumansLow-Level Light TherapyMembrane Potential, MitochondrialReactive Oxygen SpeciesSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAutophagyBlue lightCell proliferationOral squamous cell carcinomaPhotobiomodulation

Identifiers

PMID40533694

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.