Evidence map›Paper›PMID 40533669›Full record

ArticleAngiogenesis2025

Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis.

Donglu Qin, Jiarui Hu, Yang Yang, Xin Li, Jia He, Jin Chen, Xin Guo, Cheng Wei, Fengjiao Wang, Ting Yi and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Angiogenesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Donglu QinDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Jiarui HuDepartment of Spine Surgery, The Second Xiangya Hospital, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Yang YangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xin LiDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Jia HeDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Jin ChenDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Xin GuoDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Cheng WeiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Fengjiao WangDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Ting YiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Chenyu LiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Bilian YuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Research Institute of Blood Lipid and Atherosclerosis, Central South University, NO.139 Middle Renmin Road, Changsha, 410011, Hunan, China. yubilian@csu.edu.cn.

Funding

Chinese Cardiovascular Association-Access fund 2019-CCA-ACCESS-028National Natural Science Foundation of China 82170483Natural Science Foundation of Hunan Province of China 2018JJ1045Natural Science Foundation of Hunan Province of China 2020JJ4786Natural Science Foundation of Hunan Province of China 2022JJ40672Natural Science Foundation of Hunan Province of China 2023JJ40869Scientific Research Program of FuRong Laboratory 2023SK2107
6 · The paper itself

Abstract

GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethyluridine (τm

Indexed as

Activating Transcription Factor 4Endothelial CellsExtremitiesHindlimbIschemiaMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsNeovascularization, PhysiologicReactive Oxygen SpeciesAngiogenesisAnimalsMiceMice, KnockoutMitochondriaSignal TransductionActivating Transcription Factor 4Atf4 protein, mouseMechanistic Target of Rapamycin Complex 1Monomeric GTP-Binding ProteinsReactive Oxygen SpeciesAngiogenesisGTP binding protein 3Mitochondrial functionmTORC1MtROS

Identifiers

PMID40533669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.