Evidence map›Paper›PMID 40533659›Full record

ReviewBioresources and bioprocessing2025

Current breakthroughs and advances in atmospheric room temperature plasma (ARTP) technology for biomanufacturing.

Yu-Hsiu Li, Jiun-Jang Juo, I-Son Ng

Abstract readReview
In one paragraph

Review in Bioresources and bioprocessing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Mutagenesis and Analysis for Enhancing (2Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Alleviating Effects of Three Heat-InactivatedAntioxidants (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Breeding of High-Polysaccharide-ProducingJournal of fungi (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu-Hsiu LiDepartment of Chemical Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
Jiun-Jang JuoDepartment of Chemical Engineering, National Cheng Kung University, Tainan, 701, Taiwan.
I-Son NgDepartment of Chemical Engineering, National Cheng Kung University, Tainan, 701, Taiwan. yswu@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0003-1659-5814

Funding

National Science and Technology Council 111-2221-E-006-012-MY3National Science and Technology Council 113-2218-006-014
6 · The paper itself

Abstract

Atmospheric and Room Temperature Plasma (ARTP) mutagenesis has emerged as a novel and powerful physical mutation technology for microbial strain improvement recently. ARTP operates at atmospheric pressure and room temperature using a helium plasma jet, inducing widespread genomic mutations through reactive species and DNA damage. Compared to traditional mutagenesis methods, ARTP is safer, more efficient, and capable of producing high mutation rates without genetic modification, making it a valuable and sophisticated tool in biomanufacturing. This review outlines the principles and diverse applications of ARTP technology for enhancing enzyme activity, metabolite yields, and stress tolerance across various organisms. It also provides a comprehensive discussion of underlying biological mechanisms, workflow, optimization parameters, and potential cellular instability associated with ARTP-induced mutagenesis. Finally, current breakthroughs and future perspectives of ARTP mutagenesis are addressed, emphasizing its role in advancing next-generation microbial platforms for industrial biotechnology and environmental sustainability.

Indexed as

Atmospheric room temperature plasmaBiomanufacturingHigh-value chemicalMicroalgaeYeast

Identifiers

PMID40533659
PMCPMC12176711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.