ArticleNature2025
Kupffer cell programming by maternal obesity triggers fatty liver disease.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism.Nature metabolism · 2026Article
- Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling.Nature communications · 2026Article
- Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution.JCI insight · 2026Review
- CSF1R regulates monocyte subset differentiation and intracellular metabolism.Nature communications · 2026Article
- Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.Nature reviews. Immunology · 2026Review
- Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid.Nature communications · 2026Article
- SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Maternal PMParticle and fibre toxicology · 2026Article
- SLPI-Loaded Liposomes Targeting Kupffer Cells Modulate Macrophage Polarization and Mitigate Radiation-Induced Liver Damage.International journal of molecular sciences · 2026Article
- Maternal Fine Particulate Matter Exposure Impairs Inguinal White Adipose Tissue Plasticity in Middle-Aged Male Mouse Offspring.ACS nano · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Review
- Effect of nasopharyngeal airway on hypoxemia in overweight and obese patients undergoing sedated endoscopy: A randomized trial.iScience · 2026Article
- Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.Development (Cambridge, England) · 2026Article
- The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Biomedicines · 2026Review
- Developmental origins of immunometabolic health.Immunometabolism (Cobham, Surrey) · 2026Review
- Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases.Frontiers in immunology · 2026Review
- Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice.Cellular and molecular gastroenterology and hepatology · 2026Article
- Mechanistic Research on the Crosstalk Between Macrophage Polarization and Energy Metabolic Reprogramming in Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2026Review
- Circadian disruption aggravates non-alcoholic fatty liver disease by activating RIPK1-RIPK3-MLKL axis in mice.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Hao Huang *Developmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0003-3878-3947
Nora R Balzer *Developmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Lea SeepComputational Life Sciences, Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.ORCID 0000-0002-0399-1896
Iva SplichalovaDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Nelli Blank-SteinDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Maria Francesca ViolaDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0003-0660-9506
Eliana Franco TaverasDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0009-0009-2227-6765
Kerim AcilDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0009-0002-7838-9928
Diana FinkInstitute of Innate Immunity, Department of Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0009-0008-1572-4390
Franzisca PetrovicDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Nikola MakdissiDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0002-9345-038X
Seyhmus BayarDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0001-7077-8748
Katharina MauelDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0009-0007-4879-032X
Carolin RadwaniakDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0009-0007-7908-1067
Jelena ZurkovicBiochemistry and Cell Biology of Lipids, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0002-5932-4849
Amir H KayvanjooDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0003-1315-8336
Klaus WunderlingBiochemistry and Cell Biology of Lipids, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0003-1237-7510
Malin JessenDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0009-0007-5929-0064
Mohamed H YaghmourBiochemistry and Cell Biology of Lipids, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Lukas KennerClinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2184-1338
Thomas UlasSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany.ORCID 0000-0002-9785-4197
Stephan GreinComputational Life Sciences, Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.ORCID 0000-0001-9524-6633
Joachim L SchultzeSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany.
Charlotte L ScottDepartment of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium.ORCID 0000-0003-4914-6580
Martin GuilliamsDepartment of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium.
Zhaoyuan LiuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-3117-0833
Florent GinhouxShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-2857-7755
Marc D BeyerSystems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Bonn, Germany.ORCID 0000-0001-9704-148X
Christoph ThieleBiochemistry and Cell Biology of Lipids, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.ORCID 0000-0001-5161-2558
Felix MeissnerInstitute of Innate Immunity, Department of Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-1000-7989
Jan HasenauerComputational Life Sciences, Life and Medical Sciences (LIMES) Institute and Bonn Center for Mathematical Life Sciences, University of Bonn, Bonn, Germany.
Dagmar WachtenInstitute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-4800-6332
Elvira MassDevelopmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. elvira.mass@uni-bonn.de.ORCID 0000-0003-2318-2356
Funding
National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MNIDDK NIH HHS U2C DK119886
Abstract
Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis
Indexed as
Fatty LiverKupffer CellsObesityPregnancy in ObesityPrenatal Exposure Delayed EffectsAnimalsAnimals, NewbornDisease Models, AnimalFemaleGlycolysisHepatocytesHypoxia-Inducible Factor 1, alpha SubunitLiverMacrophagesMaleMiceHif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunit
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.