Evidence map›Paper›PMID 40533563›Full record

ArticleNature2025

Morphodynamics of human early brain organoid development.

Akanksha Jain, Gilles Gut, Fátima Sanchis-Calleja, Reto Tschannen, Zhisong He, Nicolas Luginbühl, Fides Zenk, Antonius Chrisnandy, Simon Streib, Christoph Harmel and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Akanksha Jain *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. akanksha.jain@bsse.ethz.ch.ORCID 0000-0003-4704-7992
Gilles Gut *Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Fátima Sanchis-CallejaDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0000-0002-8461-2068
Reto TschannenDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Zhisong HeDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0000-0002-1502-4801
Nicolas LuginbühlDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Fides ZenkDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0000-0002-0324-0902
Antonius ChrisnandyInstitute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-3851-4870
Simon StreibDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Christoph HarmelInstitute of Human Biology, Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Ryoko OkamotoDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Malgorzata SantelDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0009-0006-4947-8509
Makiko SeimiyaDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
René HoltackersDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0009-0006-7599-6684
Juliane K RohlandDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.
Sophie Martina Johanna JansenDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.ORCID 0000-0002-1985-0596
Matthias P LutolfInstitute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-5898-305X
J Gray CampInstitute of Human Biology, Roche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.ORCID 0000-0003-3295-1225
Barbara TreutleinDepartment of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland. barbara.treutlein@bsse.ethz.ch.ORCID 0000-0002-3299-5597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain organoids enable the mechanistic study of human brain development and provide opportunities to explore self-organization in unconstrained developmental systems

Indexed as

BrainMorphogenesisOrganoidsAdaptor Proteins, Signal TransducingExtracellular MatrixHumansInduced Pluripotent Stem CellsNeural CrestSingle-Cell AnalysisTelencephalonYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID40533563
PMCPMC12390842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.