ArticleNature2025
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation and gut microbial characteristics in the whole spectrum of Alzheimer's disease: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Gut microbiota dysbiosis shapes brain T-cell immunity in accelerated aging.Gut microbes · 2026Article
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- IFN-γ-Associated Signaling Networks in Interstitial Lung Disease Associated With Sjögren's Disease.Immunity, inflammation and disease · 2026Review
- Article
- Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn's disease.Journal of gastroenterology · 2026Article
- Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.Signal transduction and targeted therapy · 2026Article
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk.Molecular psychiatry · 2026Article
- Stress granule dynamics orchestrate colitis-to-cancer transition via TOM1-mediated disassembly and driven oncogenesis in response to inflammatory oxidative stress.Redox biology · 2026Article
- Inflame and restrain - the paradoxical roles of IL-12 and IL-23 in immunity.Nature reviews. Immunology · 2026Review
- Gut microbial interaction networks control autoimmunity to neuroretina.Research square · 2026Article
- Resident microbes shape host immunity and protect against pathogen infection and inflammatory disease.Cellular and molecular life sciences : CMLS · 2026Review
- Nanotherapeutic Macrophage-Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis-Induced Lung Injury and Neurologic Damage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Roseburia intestinalis ameliorates adolescent depression via GPR43‑dependent Treg cell expansion and suppression of neuroinflammation.Journal of neuroinflammation · 2026Article
- Gut T cell-microbiota crosstalk orchestrates antibacterial immunity and mucosal homeostasis in teleost.Microbiome · 2026Article
- Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility.Cell systems · 2026Article
- Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.Nature communications · 2026Article
- SUMOylation is destined for regulatory T cell-related immune dysregulation.Cell death discovery · 2026Review
- Pushing the frontier of gut microbiome health cross-kingdom and cross-organ.Nature reviews. Gastroenterology & hepatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Zachary WhiteDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.ORCID 0000-0002-4085-3580
Ivan CabreraDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Linghan MeiPritzker School of Molecular Engineering, University of Chicago, Chicago, USA.ORCID 0000-0002-0299-6839
Margarette ClevengerPritzker School of Molecular Engineering, University of Chicago, Chicago, USA.
Andrea Ochoa-RayaDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.ORCID 0000-0002-1019-166X
Isabel KapustkaDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Joseph R DominguezDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.ORCID 0000-0002-0197-8858
Jinyan ZhouDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kevin P KosterDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Shehata AnwarDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Qianxun WangDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.ORCID 0000-0001-9196-7505
Charles NgCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shoko SagoshiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Takashi MatsuoDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Dulari JayawardenaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Seung Hyeon KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Takahiro KageyamaDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Benjamin J MitchellDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Dante RiveraDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Pradeep K DudejaDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Sarah E LutzDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.ORCID 0000-0002-6388-753X
Ki-Wook KimDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Akira YoshiiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Nicolas ChevrierPritzker School of Molecular Engineering, University of Chicago, Chicago, USA.ORCID 0000-0002-9667-4506
Makoto InoueDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-3991-3806
Teruyuki SanoDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA. tsano1@uic.edu.ORCID 0000-0001-6567-4581
Funding
Molecular Mechanisms of Adjuvant Triplet CombinationsU01AI160418 · NIAID · UNIVERSITY OF CHICAGO · PI CHEVRIER, NICOLAS · 2021 to 2025
$3.1MBuilding a Predictive Framework for Adjuvant Combinatorics in Vaccine DevelopmentDP2AI145100 · NIAID · UNIVERSITY OF CHICAGO · PI CHEVRIER, NICOLAS · 2018 to 2018
$2.4MRole of membrane-associated macrophages in health and inflammationR01DK126753 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, KIWOOK · 2021 to 2025
$2.1MNIAID NIH HHS DP2 AI145100NIAID NIH HHS U01 AI160418NIDDK NIH HHS R01 DK126753
Abstract
The microbiota has been recognized as a critical contributor to various diseases
Indexed as
CD4-Positive T-LymphocytesColitisGastrointestinal MicrobiomeNeuroinflammatory DiseasesAnimalsCentral Nervous SystemFemaleGranulocyte-Macrophage Colony-Stimulating FactorInflammationInterferon-gammaInterleukin-17MaleMiceMice, Inbred C57BLMicrogliaT-Lymphocytes, RegulatoryGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaInterleukin-17
Identifiers
PMID
40533562What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.