ArticleNature genetics2025
Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
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In one paragraph
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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What it found
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Who cites it
21 citing papers in PubMed.
- A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.Nature genetics · 2026Article
- Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Biomarker-Based Diagnosis and Care Pathways for Alzheimer's Disease in the Era of Disease-Modifying Treatments: A Consensus Statement by Belgian Experts.European journal of neurology · 2026Article
- Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis.Genetic epidemiology · 2026Article
- Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.Molecular psychiatry · 2026Review
- Dissecting Alzheimer's disease heterogeneity by cross-trait polygenic prediction.bioRxiv : the preprint server for biology · 2026Article
- A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci.medRxiv : the preprint server for health sciences · 2026Article
- Are we fully exploiting genetic discoveries to understand and treat Alzheimer's disease?Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Population- and haplotype-dependent variation aroundJID innovations : skin science from molecules to population health · 2026Article
- An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity.Briefings in bioinformatics · 2026Article
- Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.medRxiv : the preprint server for health sciences · 2026Article
- Review
- Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diagnostic and treatment strategies in a memory clinic for older adults in a region with a predominantly low-income population.Frontiers in dementia · 2026Article
- Alzheimer's disease: genetic background in the era of next-generation sequencing technologies.Brain communications · 2026Review
- Toward personalized medicine in AD/ADRD through genetic-exposome dementia risk assessments.NPJ dementia · 2026Review
- Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.medRxiv : the preprint server for health sciences · 2025Article
- Special Issue: "New Trends in Alzheimer's Disease Research: From Molecular Mechanisms to Therapeutics: 2nd Edition".International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
203 authors.
Aude Nicolas *U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France. dr.aude.nicolas.deydier@gmail.com.ORCID http://orcid.org/0009-0005-2606-2765
Richard Sherva *Behavioral Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2133-1493
Benjamin Grenier-Boley *U1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.
Yoontae Kim *BK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.ORCID http://orcid.org/0009-0008-0913-006X
Masataka KikuchiGraduate School of Frontier Science, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9562-841X
Jigyasha TimsinaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Itziar de RojasACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2148-381X
María Carolina DalmassoDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, Division of Neurogenetics and Molecular Psychiatry, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-4901-9955
Xiaopu ZhouDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China.ORCID http://orcid.org/0000-0001-5307-5805
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6649-8364
Carlos E Arboleda-BustosNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Maria Aparecida Camargos BicalhoDepartment of Clinical Medicine, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil.ORCID http://orcid.org/0000-0001-6298-9377
Maëlenn GuerchetEpiMaCT - Epidemiology of chronic diseases in tropical zone, Inserm U1094, IRD UMR270, Université Limoges, CHU Limoges, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.ORCID http://orcid.org/0000-0002-0470-5556
Sven van der LeeDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Monica GossGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
Atahualpa CastilloDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
Céline BellenguezU1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID http://orcid.org/0000-0002-1240-7874
Fahri KüçükaliComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3835-9639
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-1115-4430
Bernard FongangGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-8161-1553
Qiong YangBoston University and the NHLBI's Framingham Heart Study, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.ORCID http://orcid.org/0000-0003-0568-2998
Anja SchneiderGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-9540-8700
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Dan RujescuDepartment of Psychiatry and Comprehensive Center of Neuroscience and Mental Health, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-1432-313X
Norbert ScherbaumDepartment of Psychiatry and Psychotherapy, LVR-University Hospital Essen, Medical Faculty of the University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-1759-6990
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4321-6090
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9009-2356
Laura Molina-PorcelNeurological Tissue Bank - Biobanc, Hospital Clinic, FRCB, IDIBAPS, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4068-8578
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Timo GrimmerDepartment of Psychiatry and Psychotherapy, Center for Cognitive Disorders, Technical University of Munich, School of Medicine, Munich, Germany.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.ORCID http://orcid.org/0000-0003-1492-5330
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-1057-465X
Susanne MoebusInstitute for Urban Public Health, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-0072-5410
Thomas TegosFirst Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Nikolaos ScarmeasFirst Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Oriol Dols-IcardoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2656-8748
Fermin MorenoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-5200-3164
Jordi Pérez-TurCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-9111-1712
María J BullidoCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6477-1117
Pau PastorDepartment of Neurology, Unit of Neurodegenerative Diseases, University Hospital Germans Trias i Pujol, Badalona, Spain.ORCID http://orcid.org/0000-0002-7493-8777
Raquel Sánchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Victoria ÁlvarezLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.ORCID http://orcid.org/0000-0002-1916-2523
Han CaoDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China.ORCID http://orcid.org/0000-0001-9992-9108
Nancy Y IpDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China.ORCID http://orcid.org/0000-0002-2763-8907
Amy K Y FuDivision of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Kowloon, China.
Fanny C F IpHong Kong Center for Neurodegenerative Diseases, Hong Kong, China.ORCID http://orcid.org/0000-0001-5162-1761
Natividad OlivarCenter of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0003-4598-6865
Carolina MuchnikCenter of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-1542-3706
Carolina CuestaHospital Interzonal General de Agudos-Eva Perón, Buenos Aires, Argentina.
Lorenzo CampanelliLaboratory of Brain Aging and Neurodegeneration. Fundacion Instituto Leloir-IIBBA, Buenos Aires, Argentina.
Patricia SolisStudies in Neuroscience and Complex Systems Unit-CONICET-HEC-UNAJ, Buenos Aires, Argentina.
Daniel Gustavo PolitisHospital Interzonal General de Agudos-Eva Perón, Buenos Aires, Argentina.
Silvia KochenStudies in Neuroscience and Complex Systems Unit-CONICET-HEC-UNAJ, Buenos Aires, Argentina.
Luis Ignacio BruscoCenter of Neuropsychiatry and Behavior Neurology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
Mercè BoadaACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2617-3009
Pablo García-GonzálezACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0125-5403
Raquel PuertaACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1191-5893
Pablo MirCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-1656-302X
Luis M RealCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-4932-7429
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Jose María García-AlbercaCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0003-2951-6644
Jose Luís RoyoDepatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
Eloy Rodriguez-RodriguezCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-7742-677X
Hilkka SoininenInstitute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2785-9937
Sami HeikkinenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-6083-2402
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Shima MehrabianClinic of Neurology, UH Alexandrovska, Medical University, Sofia, Bulgaria.
Latchezar TraykovDepartment of Neurology, UH Alexandrovska, Medical University, Sofia, Bulgaria.
Jakub HortDepartment of Neurology, Memory Clinic, Charles University, Second Faculty of Medicine and Motol University Hospital, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-1080-3726
Martin VyhnalekDepartment of Neurology, Memory Clinic, Charles University, Second Faculty of Medicine and Motol University Hospital, Brno, Czech Republic.
Katrine Laura RasmussenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3484-9531
Yolande A L PijnenburgDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Henne HolstegeDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7688-3087
John C van SwietenAlzheimer Center, Department of Neurology, Erasmus MR, Rotterdam, the Netherlands.
Harro SeelaarAlzheimer Center, Department of Neurology, Erasmus MR, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1989-7527
Jurgen A H R ClaassenDepartment of Geriatrics, Radboud University Medical Center, Research Institute for Medical Innovation, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-1778-8151
Willemijn J JansenDepartment of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
Inez RamakersDepartment of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
Frans VerheyDepartment of Psychiatry and Neuropsychology, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
Aad van der LugtDepartment of Radiology, ErasmusMC, Rotterdam, the Netherlands.
Philip ScheltensDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-1046-6408
Jenny Ortega-RojasNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Ana Gabriela Concha MeraNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Maria F MahechaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.ORCID http://orcid.org/0000-0002-2306-5216
Rodrigo PardoNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Gonzalo ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Shahram BahramiDivision of Mental Health and Addiction, NORMENT Centre, Oslo University Hospital, Oslo, Norway.
Vera FominykhDivision of Mental Health and Addiction, NORMENT Centre, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-5490-2390
Geir SelbækNorwegian Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.ORCID http://orcid.org/0000-0001-6511-8219
Caroline GraffUnit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden.
Goran PapenbergDepartment of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Vilmantas GiedraitisDepartment of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Anne BolandUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Evry, France.ORCID http://orcid.org/0000-0001-8789-5676
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), Evry, France.
Luiz Armando de MarcoNational Institute of Science and Technology (INCT) Neurotec R, Federal University of Minas Geraes Belo Horizonte, Minas Geraes, Brazil.
Edgar Nunes de MoraesDepartment of Clinical Medicine, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil.
Bernardo de Mattos VianaNational Institute of Science and Technology (INCT) Neurotec R, Federal University of Minas Geraes Belo Horizonte, Minas Geraes, Brazil.
Marco Túlio Gualberto CintraDepartment of Clinical Medicine, Federal University of Minas Gerais (UFMG) Belo Horizonte, Minas Geraes, Brazil.
Teresa Juarez-CedilloUnidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-9442-3471
Anthony J GriswoldThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Tatiana ForundDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Jonathan HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
Lindsay FarrerDepartment of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5533-4225
Anita DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ellen WijsmanDepartment of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2725-6669
Richard MayeuxDepartment of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6519-9696
Margaret Pericak-VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.ORCID http://orcid.org/0000-0001-7283-8804
Brian KunkleThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Alison GoateDepartment of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Badri VardarajanDepartment of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-5560-4085
Li-San WangDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Yuk Yee LeungDepartment of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3047-5440
Clifton L DalgardDepartment of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2025-8239
Gael NicolasDepartment of Genetics and CNR-MAJ, Université Rouen Normandie, Normandie Université, Inserm U1245 and CHU Rouen, Rouen, France.ORCID http://orcid.org/0000-0001-9391-7800
David WallonDepartment of Genetics and CNR-MAJ, Université Rouen Normandie, Normandie Université, Inserm U1245 and CHU Rouen, Rouen, France.ORCID http://orcid.org/0000-0002-2634-7198
Carole DufouilBordeaux Population Health Research Center, Inserm, UMR 1219, Université Bordeaux, ISPED, CIC 1401-EC, Université Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0003-2442-4476
Florence PasquierCHU Clinical and Research Memory Research Centre (CMRR) of Distalz Lille France, Université Lille Inserm 1171, Paris, France.
Olivier HanonHôpital Broca, Université de Paris, EA 4468, APHP, Paris, France.
Stéphanie DebetteBordeaux Population Health Research Center, University Bordeaux, Inserm, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8505-7265
Julius PoppDepartment of Psychiatry, Old Age Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Bárbara AngelPublic Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0001-8773-5904
Sergio GlogerBiomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile.ORCID http://orcid.org/0000-0002-8674-1306
Maria Victoria ChaconBiomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile.
Rafael AranguizBiomedica Research Group, Centro de Estudios Clínicos, Santiago, Chile.
Paulina OrellanaGeroscience Center for Brain Health and Metabolism, Santiago, Chile.ORCID http://orcid.org/0000-0001-8752-7750
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism, Santiago, Chile.
Christian Gonzalez-BillaultPublic Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0003-0335-1482
Cecilia AlbalaPublic Health Nutrition Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0002-6135-334X
Patricio FuentesGeriatrics Section Clinical Hospital University of Chile, Santiago de Chile, Chile.
Perminder SachdevCentre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Karen A MatherCentre for Healthy Brain Ageing School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Richard L HaugerCenter of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-1509-1868
Victoria MerrittVA San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-5683-4168
Matthew PanizzonCenter for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA, USA.
Rui ZhangBehavioral Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.ORCID http://orcid.org/0000-0002-7691-1957
Daniela GalimbertiNeurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0002-9284-5953
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-0615-3580
Patrizia MecocciInstitute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0003-0729-5246
Vincenzo SolfrizziInterdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari A. Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-8524-0315
Lucilla ParnettiCentre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0001-5722-3967
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Lucio TremolizzoNeurology, IRCCS San Gerardo dei Tintori, Monza and University of Milano-Bicocca, Milano, Italy.
Barbara BorroniDeaprtment of Clinical and Experimental Sciences, University of Brescia Italy, Brescia, Italy.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-9338-9040
Paolo CaffarraPast Director Dementia Unit University of Parma, Parma, Italy.
Davide SeripaDepartment of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
Innocenzo RaineroDepartment of Neuroscience Rita Levi Montalcini, University of Torino, Turin, Italy.
Antonio DanieleDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Fabrizio PirasLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
EADB
Hampton L LeonardCenter for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.
Jenifer S YokoyamaDataTecnica LLC, Washington, DC, USA.ORCID http://orcid.org/0000-0001-7274-2634
Mike A NallsCenter for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0319-4325
Akinori MiyashitaNiigata University, Brain Research Institute, Niigata, Japan.ORCID http://orcid.org/0000-0003-2508-9649
Norikazu HaraNiigata University, Brain Research Institute, Niigata, Japan.ORCID http://orcid.org/0000-0001-8525-3469
Kouichi OzakiResearch Center, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID http://orcid.org/0000-0003-0028-1570
Shumpei NiidaResearch Center, National Center for Geriatrics and Gerontology, Obu, Japan.
Julie WilliamsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-4069-0259
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
Philippe AmouyelU1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Pierre-Marie PreuxEpiMaCT - Epidemiology of chronic diseases in tropical zone, Inserm U1094, IRD UMR270, Université Limoges, CHU Limoges, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
Pascal MbelessoEpiMaCT - Epidemiology of chronic diseases in tropical zone, Inserm U1094, IRD UMR270, Université Limoges, CHU Limoges, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
Bébène BandzouziDepartment of Neurology, Brazzaville University Hospital, Brazzaville, Republic of Congo.
Andy SaykinDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1376-8532
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Patrick G KehoeTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7542-1139
Cornelia Van DuijnDepartment of Epidemiology, ErasmusMC, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Nesrine Ben SalemHigh Institute of Biotechnology, University of Monastir, Monastir, Tunisia.
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4084-5027
Lotfi CherniHigh Institute of Biotechnology, University of Monastir, Monastir, Tunisia.
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Magda TsolakiFirst Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-2072-8010
Pascual Sánchez-JuanCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
Marco Aurélio Romano SilvaNational Institute of Science and Technology (INCT) Neurotec R, Federal University of Minas Geraes Belo Horizonte, Minas Geraes, Brazil.ORCID http://orcid.org/0000-0002-6558-4639
Tenielle PorterCentre for Precision Health, Edith Cowan University, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0002-7887-6622
Simon M LawsCentre for Precision Health, Edith Cowan University, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0002-4355-7082
Kristel SleegersComplex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-0283-2332
Martin IngelssonDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-5466-8370
Jean-François DartiguesBordeaux Population Health Research Center, INSERM, Bordeaux UMR 1219, Bordeaux, France.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6135-2622
Giacomina RossiFondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID http://orcid.org/0000-0001-6680-2725
Laura MorelliLaboratory of Brain Aging and Neurodegeneration. Fundacion Instituto Leloir-IIBBA, Buenos Aires, Argentina.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Rebecca SimsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-3885-1199
Wiesje van der FlierDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8766-6224
Ole A AndreassenDivision of Mental Health and Addiction, NORMENT Centre, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Humberto ArboledaNeuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0276-2899
Valentina Escott-PriceUK Dementia Research Institute, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-1784-5483
Agustín RuizACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2633-2495
Kun Ho LeeBK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0003-4144-8162
Takeshi IkeuchiNiigata University, Brain Research Institute, Niigata, Japan.ORCID http://orcid.org/0000-0001-8828-8085
Alfredo RamirezGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0003-4991-763X
Jungsoo GimBK FOUR Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.
Mark LogueBehavioral Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9347-7892
Jean-Charles LambertU1167-RID-AGE facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.ORCID http://orcid.org/0000-0003-0829-7817
Funding
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MRio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for ProgressP30AG059305 · NIA · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Eron Grant Manusov · 2018 to 2026
$5.8MBuilding Unique Infrastructure for Large-scale Dementia research in French-Speaking Africa (BUILD-FSA) ProjectUG3AG090675 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Bernard Fongang, Alfred Kongnyu Njamnshi · 2025 to 2026
$992kDelineating the role of the gut microbiota and its derived metabolites in the development of dementia in multi-ethnic populationsK01NS126489 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Bernard Fongang · 2023 to 2026
$882kBLRD VA I01 BX005749NIA NIH HHS P30 AG059305NIA NIH HHS P30 AG066546NIA NIH HHS UG3 AG090675NINDS NIH HHS K01 NS126489
Abstract
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.
Indexed as
Alzheimer DiseaseGenetic Predisposition to DiseaseMultifactorial InheritanceWhite PeopleAgedApolipoproteins EBiomarkersEuropeFemaleGenetic Risk ScoreGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideRisk FactorsApolipoproteins EBiomarkers
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