Evidence map›Paper›PMID 40533503›Full record

ArticlePediatric research2025

Early antibiotic exposure and the risk of necrotizing enterocolitis in preterm neonates: insights from a large multicenter cohort in China.

Xuelian Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Xuelian WangDepartment of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China. xuelianwan@sina.cn.ORCID http://orcid.org/0000-0001-6613-7366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between early antibiotic overuse in preterm neonates and the risk of necrotizing enterocolitis (NEC) remains controversial. In this issue of Pediatric Research, Zhu et al. present findings from a large multicenter prospective cohort study across China, reporting no significant association between early empirical antibiotic exposure and NEC. However, prolonged use of broad-spectrum antibiotics was associated with increased mortality. The results underscore the importance of antibiotic stewardship in neonatal care and highlight the need for further randomized trials and mechanistic studies to better understand the complex interactions between antibiotics and NEC pathogenesis. IMPACT: This comment highlights the study by Zhu et al. 'Early antibiotic exposure and necrotizing enterocolitis among preterm infants <34 weeks' gestation'.

Indexed as

Anti-Bacterial AgentsEnterocolitis, NecrotizingInfant, Premature, DiseasesChinaCohort StudiesGestational AgeHumansInfant, NewbornInfant, PrematureMulticenter Studies as TopicProspective StudiesRisk FactorsAnti-Bacterial Agents

Identifiers

PMID40533503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.