Evidence map›Paper›PMID 40533502›Full record

ArticlePediatric research2025

A two-hit model in biliary atresia: cooperative viral-bacterial activation of MMP7 via TLR4/NF-κB signaling.

Khaled Saad, Mostafa M Embaby, Thamer A M Alruwaili, Amira Elhoufey, Mohamad-Hani Temsah, Wesam M Hussein, Mohamed Abdelsaboor, Khalid Hashim Mahmoud

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Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khaled SaadDepartment of Pediatrics, Assiut University, Assiut, Egypt. khaled.ali@med.au.edu.eg.ORCID http://orcid.org/0000-0002-8473-6116
Mostafa M EmbabyDepartment of Pediatrics, Assiut University, Assiut, Egypt.
Thamer A M AlruwailiDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
Amira ElhoufeyDepartment of Community Health Nursing, Alddrab University College, Jazan University, Jazan, Saudi Arabia.
Mohamad-Hani TemsahPediatric Intensive Care Unit, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Wesam M HusseinChemistry Department, Faculty of Science, Islamic University of Madinah, Madinah, Saudi Arabia.
Mohamed AbdelsaboorDepartment of Pediatrics, Aswan University, Aswan, Egypt.
Khalid Hashim MahmoudDepartment of Pediatrics, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impactRhesus rotavirus (RRV) infection primes biliary epithelial cells to respond hyperactively to low-dose lipopolysaccharide (LPS), triggering upregulation of matrix metalloproteinase-7 (MMP7) via TLR4/NF-κB signaling. Loss of endotoxin tolerance in biliary atresia (BA), associated with reduced expression of IRAK-M, leads to uncontrolled inflammation and tissue damage. MMP7 acts as a dual-function molecule, contributing to both extracellular matrix remodeling and amplification of inflammatory signaling in BA. Targeting the TLR4/NF-κB/MMP7 signaling axis represents a promising therapeutic strategy with potential applications in disease modification and early diagnosis of BA.

Indexed as

Biliary AtresiaMatrix Metalloproteinase 7NF-kappa BRotavirus InfectionsSignal TransductionToll-Like Receptor 4AnimalsEpithelial CellsHumansInterleukin-1 Receptor-Associated KinasesLipopolysaccharidesRotavirusInterleukin-1 Receptor-Associated KinasesLipopolysaccharidesMatrix Metalloproteinase 7MMP7 protein, humanNF-kappa BTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID40533502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.