Evidence map›Paper›PMID 40533452›Full record

ReviewNPJ Parkinson's disease2025

Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities.

Mathangi Palanivel, Krishna Kanta Ghosh, Madhav Mallam, Raghavan Bhuvanakantham, Parasuraman Padmanabhan, Kah-Leong Lim, Balázs Gulyás

Abstract readReview
In one paragraph

Review in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mathangi PalanivelLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Krishna Kanta GhoshLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Madhav MallamLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Raghavan BhuvanakanthamLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Parasuraman PadmanabhanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. ppadmanabhan@ntu.edu.sg.
Kah-Leong LimLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. kahleong.lim@ntu.edu.sg.
Balázs GulyásLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. balazs.gulyas@ntu.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying non-motor biomarkers during this prodromal phase could predict phenoconversion and enable early interventions. This narrative review outlines key prodromal non-motor symptoms, summarizes imaging technologies for early detection, and explores their translational potential in guiding timely, neuroprotective therapies for at-risk individuals.

Identifiers

PMID40533452
PMCPMC12177059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.