Evidence map›Paper›PMID 40533354›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [

Ye Xia, Maeva Dhaynaut, Yanis Chemli, Cristina Lois, Bernard J Hanseeuw, Emma Thibault, Colin Groot, Rik Ossenkoppele, Keith Johnson, Georges El Fakhri and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ye XiaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Maeva DhaynautDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Yanis ChemliDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Cristina LoisDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Bernard J HanseeuwDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Emma ThibaultDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Colin GrootAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Rik OssenkoppeleAlzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Keith JohnsonDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Georges El FakhriDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Marc D NormandinDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Nicolas J GuehlDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; nicolas.guehl@yale.edu.

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Disentangling the contribution of tau to aging and ADR01AG046396 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON, KEITH A. · 2014 to 2018
$4.0M
Methods for Quantitative Neuroimaging of Tau Burden inPre-symptomatic ADR01AG076153 · NIA · YALE UNIVERSITY · PI Georges El Fakhri, Marc David Normandin · 2022 to 2026
$3.0M
Disentangling specific and off-target signals in tau PET imagingR21AG070714 · NIA · YALE UNIVERSITY · PI GUEHL, NICOLAS JEAN · 2021 to 2022
$420k
NIA NIH HHS R01 AG046396NIA NIH HHS R01 AG076153NIA NIH HHS R21 AG070714NIBIB NIH HHS P41 EB022544
6 · The paper itself

Abstract

This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-

Indexed as

IsoquinolinesPositron-Emission Tomographytau ProteinsAgedAged, 80 and overAlzheimer DiseaseBrainCognitive DysfunctionFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedTime FactorsIsoquinolinesMK-6240tau Proteins[18F]MK6240Alzheimer diseasedual-time-window imagingPETtau imaging

Identifiers

PMID40533354
PMCPMC12320581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.