Evidence map›Paper›PMID 40533239›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Methotrexate-associated Angioimmunoblastic T-cell Lymphoma Presenting with Acute Kidney Injury.

Satoshi Ichikawa, Hikaru Kumagai, Koichi Onodera, Yoko Okitsu, Masahiro Kobayashi, Shori Abe, Fumiyoshi Fujishima, Ryo Ichinohasama, Junichi Kameoka, Tomonori Ishii

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Satoshi IchikawaDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Hikaru KumagaiDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Koichi OnoderaDepartment of Hematology, Tohoku University Hospital, Japan.
Yoko OkitsuDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Masahiro KobayashiDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Shori AbeDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Fumiyoshi FujishimaDivision of Diagnostic Pathology, Tohoku Medical and Pharmaceutical University, Japan.
Ryo IchinohasamaDepartment of Hematopathology, Tohoku University Hospital, Japan.
Junichi KameokaDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.
Tomonori IshiiDivision of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A man in his 60s on methotrexate for rheumatoid arthritis developed a fever and lymph node swelling, suggesting a lymphoproliferative disorder. Methotrexate was discontinued; however, the patient was admitted for acute kidney injury (AKI) and thrombocytopenia. Blood tests showed high levels of inflammatory markers, positive plasma Epstein-Barr virus DNA, and CD10-positive abnormal T cells, indicating T-cell neoplasm. CHOP chemotherapy with continuous hemodiafiltration improved the patient's condition. A lymph node biopsy confirmed the diagnosis of angioimmunoblastic T-cell lymphoma (AITL). To our knowledge, this is the first reported case of methotrexate-associated AITL complicated by AKI with a successful treatment course.

Indexed as

Acute Kidney InjuryAntirheumatic AgentsImmunoblastic LymphadenopathyLymphoma, T-CellMethotrexateAntineoplastic Combined Chemotherapy ProtocolsArthritis, RheumatoidCyclophosphamideDoxorubicinHumansMaleMiddle AgedPrednisoneVincristineAntirheumatic AgentsCyclophosphamideDoxorubicinMethotrexatePrednisoneVincristineacute kidney injuryangioimmunoblastic T-cell lymphomaEpstein-Barr virusimmune deficiency and dysregulation-associated lymphoproliferative disordermethotrexate-associated lymphoproliferative disorder

Identifiers

PMID40533239
PMCPMC12854944

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.