ArticleInternal medicine (Tokyo, Japan)2026
Vonoprazan vs. Esomeprazole: Scarring Rate of Post-endoscopic Submucosal Dissection Ulcers in the Postoperative Stomach.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Proton pump inhibitors (PPIs) are ineffective in suppressing gastric acid secretion after prolonged exposure to an acidic environment in the stomach. In this study, we compared vonoprazan (VPZ) and PPI esomeprazole (EPZ) according to the rate of ulcer scarring after gastric endoscopic submucosal dissection (ESD) in the postoperative stomach, where food residues are often observed, and we investigated their effectiveness in clinical practice. Methods We compared 56 lesions treated with VPZ (20 mg) and 52 lesions treated with EPZ (20 mg) in the postoperative stomach and retrospectively evaluated the scarring rate of post-ESD ulcers at 8 weeks. ESD was performed in our hospital between January 2011 and May 2023. Results The post-ESD ulcer scarring rate after eight weeks was significantly higher in the VPZ group than in the EPZ group (83.9% vs. 57.7%, p<0.01). In the respective groups, the mean age was 72.8 and 70.8 years, food residual rate were 41.1% and 30.8%, the mean resection area was 770.0 and 1,282.4 mm
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