Evidence map›Paper›PMID 40532929›Full record

ArticleJournal of molecular biology2025

The C-terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover.

Emilie J Korchak, Dane H Geddes-Buehre, Irina Bezsonova

Abstract read
In one paragraph

Article in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. High-pH NMR to Identify Macromolecular Hydrogen-Bonds and Foldons.bioRxiv : the preprint server for biology · 2026
    Article
  4. Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emilie J KorchakDepartment of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06032, United States.
Dane H Geddes-BuehreDepartment of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06032, United States.
Irina BezsonovaDepartment of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06032, United States. Electronic address: bezsonova@uchc.edu.

Funding

UBIQUITIN-PROTEASOME PATHWAY IN CANCERR35GM128864 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BEZSONOVA, IRINA · 2018 to 2022
$1.6M
UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASER35GM156397 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Irina Bezsonova · 2025 to 2026
$1000k
Understanding the effect of Hao-Fountain syndrome-causing mutations on neuronal developmentR21NS135343 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI BEZSONOVA, IRINA, O'NEIL, ALISON LINSLEY · 2024 to 2024
$462k
NIGMS NIH HHS R35 GM128864NIGMS NIH HHS R35 GM156397NINDS NIH HHS R21 NS135343
6 · The paper itself

Abstract

USP7 is a key ubiquitin-specific protease involved in human development. Its activity is regulated by an intramolecular interaction between the catalytic domain and the unstructured C-terminal tail. Using

Indexed as

UbiquitinUbiquitin-Specific Peptidase 7Catalytic DomainHumansModels, MolecularNuclear Magnetic Resonance, BiomolecularProtein BindingProtein ConformationUbiquitinUbiquitin-Specific Peptidase 7USP7 protein, humancatalytic cysteineDUBenzyme activationNMRUSP7

Identifiers

PMID40532929
PMCPMC12351552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.