Evidence map›Paper›PMID 40532696›Full record

ArticleCell2025

Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians.

Yi Xian Er, Soo Ching Lee, Chioma Aneke, Sean Conlan, Azdayanti Muslim, Clay Deming, You Che, Nan Jiun Yap, Mian Zi Tee, Nurmanisha Abdull-Majid and 13 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Yi Xian ErDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Soo Ching LeeLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chioma AnekeMicrobiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Sean ConlanMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Azdayanti MuslimDepartment of Medical Microbiology and Parasitology, Faculty of Medicine, Universiti Teknologi MARA (Sungai Buloh Campus), 47000 Sungai Buloh, Malaysia; Institute for Biodiversity and Sustainable Development, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.
Clay DemingMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
You CheDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nan Jiun YapDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Mian Zi TeeDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Nurmanisha Abdull-MajidDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Shezryna ShahrizalDepartment of Medical Microbiology and Parasitology, Faculty of Medicine, Universiti Teknologi MARA (Sungai Buloh Campus), 47000 Sungai Buloh, Malaysia.
Kin Fon LeongDermatology Unit, Women and Children Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Malaysia.
Jungmin HanDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Zeyang ShenMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Leslie Thian Lung ThanDepartment of Medical Microbiology, Universiti Putra Malaysia, UPM, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
Morgan ParkNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Izandis Mohd SayedHospital Orang Asli (Aborigines) Gombak, Jalan Pahang Lama, 53100 Kuala Lumpur, Malaysia.
NISC Comparative Sequencing ProgramNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Amir SeyedmousaviMicrobiology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: heidi.kong@nih.gov.
P'ng LokeLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: png.loke@nih.gov.
Julia A SegreMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jsegre@nhgri.nih.gov.
Yvonne Ai Lian LimDepartment of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Centre for Malaysian Indigenous Studies, Universiti Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: limailian@um.edu.my.

Funding

Regulation of mucosal immune responses by helminth infectionsZIAAI001255 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LOKE, P'NG · 2020 to 2025
$6.1M
Studies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3M
Transcriptional Regulation of Epidermal DifferentiationZ01HG000180 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2001 to 2008
$2.4M
Investigation of the natural history and pathogenesis of skin diseasesZIAAR041218 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$745k
The skin microbiome and fungal infections of indigenous MalaysiansR01AI183416 · NIAID · UNIVERSITY OF MALAYA · PI Yvonne AL Lim · 2024 to 2026
$375k
Molecular Epidemiology of Clinically Important Fungi and Pathobiology of Fungal InfectionsZIACL090088 · CLC · CLINICAL CENTER · PI SEYEDMOUSAVI, AMIR · 2022 to 2025
$0k
Intramural NIH HHS Z01 HG000180Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AI001255Intramural NIH HHS ZIA AR041218Intramural NIH HHS ZIA AR041219Intramural NIH HHS ZIA CL090088NIAID NIH HHS R01 AI183416
6 · The paper itself

Abstract

Recent outbreaks of multidrug-resistant fungi infecting human skin emphasize the importance of understanding fungal pathophysiology and spread. In efforts to address health concerns with various Indigenous Peninsular Malaysians (Orang Asli [OA]), tinea imbricata-a Trichophyton concentricum fungal skin infection-emerged as a particular concern. We investigated the etiology and transmission of tinea imbricata by culturing, testing antifungal sensitivities, and sequencing T. concentricum isolates in remote OA villages. Among regionally conserved isolates, we identified the emergence of terbinafine-resistant T. concentricum microbiologically and genomically. Investigating the skin microbiomes of 82 Indigenous OA, we found unique microbiota and lower relative abundances of bacterial commensals (Cutibacterium acnes, Staphylococcus epidermidis) among OA versus Malaysian and US urban populations, emphasizing how understudied populations provide unprecedented knowledge on host-microbiome co-evolution. These findings provide valuable insights into clinical, microbiological, and genomic features of chronic fungal skin infections, offering the potential to inform strategies to address drug resistance and effective therapy.

Indexed as

MicrobiotaSkinTineaTrichophytonAdultAntifungal AgentsDrug Resistance, FungalFemaleHumansMalaysiaMaleMiddle AgedSoutheast Asian PeopleTerbinafineYoung AdultAntifungal AgentsTerbinafinefungiIndigenousmetagenome-assembled genomesskin microbiomestrain sharingterbinafine resistancetineaTrichophytonurbanization

Identifiers

PMID40532696
PMCPMC12335371

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.