Evidence map›Paper›PMID 40532519›Full record

ArticleParkinsonism & related disorders2025

Differential associations between retro walking versus forward walking, axial motor features and body composition in Parkinson's disease.

Chatkaew Pongmala, Chernkhuan Stonsaovapak, Miriam van Emde Boas, Nicolaas I Bohnen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chatkaew PongmalaFunctional Neuroimaging, Cognitive & Mobility Laboratory, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, 48105, USA. Electronic address: pchatkae@umich.edu.
Chernkhuan StonsaovapakDepartment of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Miriam van Emde BoasFunctional Neuroimaging, Cognitive & Mobility Laboratory, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, 48105, USA.
Nicolaas I BohnenFunctional Neuroimaging, Cognitive & Mobility Laboratory, University of Michigan, Ann Arbor, MI, USA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Morris K. Udall Center of Excellence in Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, 48105, USA; Department of Neurology University of Michigan, Ann Arbor, MI, USA; Neurology Service & GRECC, VA Medical Center, Ann Arbor, MI, USA.

Funding

Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAUER, WILLIAM T. · 2014 to 2019
$10.1M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
NIA NIH HHS R01 AG073100NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856RRD VA I01 RX001631
6 · The paper itself

Abstract

backgroundPostural instability and gait difficulties (PIGD) are a significant cause of falls, and immobility in Parkinson's disease (PD). Most gait assessments are based on assessing forward walking compared to retro walking. Retro walking is more difficult because of absence of visual cues, and more complex multisensory processing. Little is known about clinical PIGD motor features, mobility and body composition correlates of retro-walking compared to forward walking in PD.

objectiveTo examine the associations between retro and forward walking and PIGD in PD.

methods78 PD underwent clinical and body composition assessments. Multivariate logistic and linear forward stepwise regression analyses with were conducted to examine associations of retro- and forward walking times with PIGD motor features (falls, imbalance, FoG) and with clinical, body composition, and motor parameters.

resultsLogistic regression revealed that retro walking was associated with impaired balance (p = 0.028), and falls (p = 0.027) while forward walking was associated with FoG (p = 0.047). Moreover, Mini-BESTest reactive postural control (p < 0.001), waist circumference (p = 0.001), lean mass (p = 0.01), and appendicular lean mass index (p = 0.016) were associated with retro walking, while only Mini-BESTest dynamic gait (p = 0.002) was associated with forward walking.

conclusionsThere are unique associations between specific PIGD features and body composition for retro walking. Retro walking may be used to assess impaired balance and falls in PD while forward walking could be used for FoG. Poor reactive postural control, lower lean mass and higher waist circumference associated with retro walking while poor dynamic gait associated with forward walking.

Indexed as

Body CompositionGait Disorders, NeurologicParkinson DiseasePostural BalanceWalkingAccidental FallsAgedFemaleHumansMaleMiddle AgedFallsFoGForward walkingImbalancePIGDRetro walking

Identifiers

PMID40532519
PMCPMC12337005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.