Evidence map›Paper›PMID 40532495›Full record

ArticleSocial science & medicine (1982)2025

Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries.

Eric T Klopack, Belinda Hernandez, Claire Potter, Jessica D Faul, Claire Hill, Laura Smyth, Colter Mitchell, Cathal McCrory, Rose Anne Kenny, Amy Jayne McKnight and 2 more

Abstract read
In one paragraph

Article in Social science & medicine (1982), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eric T KlopackUniversity of Southern California, Leonard Davis School of Gerontology, United States. Electronic address: klopack@usc.edu.
Belinda HernandezThe Irish Longitudinal Study on Ageing, Dept. of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Claire PotterCentre for Public Health, Queens University Belfast, United Kingdom.
Jessica D FaulUniversity of Michigan, United States.
Claire HillCentre for Public Health, Queens University Belfast, United Kingdom.
Laura SmythCentre for Public Health, Queens University Belfast, United Kingdom.
Colter MitchellUniversity of Michigan, United States.
Cathal McCroryThe Irish Longitudinal Study on Ageing, Dept. of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Rose Anne KennyThe Irish Longitudinal Study on Ageing, Dept. of Medical Gerontology, School of Medicine, Trinity College Dublin, Ireland.
Amy Jayne McKnightCentre for Public Health, Queens University Belfast, United Kingdom.
Bernadette McGuinnessCentre for Public Health, Queens University Belfast, United Kingdom.
Eileen M CrimminsUniversity of Southern California, Leonard Davis School of Gerontology, United States.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Health and Retirement Study: Harmonized Cognitive Assessment Protocol (HCAP)U01AG058499 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M · 2018 to 2023
$8.3M
Social Circumstances and Epigenomics Promoting Health in Three CountriesR01AG068937 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, FAUL, JESSICA · 2020 to 2025
$2.9M
Biological Underpinnings of Socioeconomic Differentials in Health and MortalityR01AG060110 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M · 2018 to 2022
$2.6M
Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRDRF1AG088003 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRIMMINS, EILEEN M, GROSS, ALDEN L. · 2024 to 2024
$2.4M
NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG060110NIA NIH HHS R01 AG068937NIA NIH HHS RF1 AG088003NIA NIH HHS T32 AG000037NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG058499Wellcome Trust
6 · The paper itself

Abstract

Research utilizing epigenetic clocks has accelerated in recent years, but it is largely unknown how consistently these measures perform across country and cultural contexts, and thus, how useful they are for understanding the large differences in health outcomes across countries. We assess epigenetic aging in three countries (the US, Ireland, and Northern Ireland) utilizing survey data from each country and evaluated how these measures are associated with three well-studied health behaviors (heavy alcohol use, smoking, and BMI). In general, we found remarkable consistency across these studies, suggesting epigenetic clocks are potentially highly useful for monitoring health and aging processes in different contexts. More research is needed on other health risks and in non-Western and low- and middle-income countries.

Indexed as

Epigenesis, GeneticHealth BehaviorAdultAgedAgingAlcohol DrinkingBody Mass IndexFemaleHumansIrelandMaleMiddle AgedNorthern IrelandSmokingUnited StatesAgingBiological agingEpigenetic clocksHealth behaviorsInternational comparison

Identifiers

PMID40532495
PMCPMC12422063

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.