Evidence map›Paper›PMID 40532286›Full record

ArticleClinical neurology and neurosurgery2025

Distinct symptom recoveries based upon highest level of care in patients with sport-related concussion or traumatic brain injury and Glasgow Coma Scale 13-15.

Shawn R Eagle, Bryan Lamb, Daniel Huber, Michael A McCrea, Sergey Tarima, Terri A deRoon-Cassini, David O Okonkwo, Lindsay D Nelson

Abstract read
In one paragraph

Article in Clinical neurology and neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shawn R EagleDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: Eaglesr2@upmc.edu.
Bryan LambDepartment of Physical Medicine & Rehabilitation, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: blamb@alumni.nd.edu.
Daniel HuberDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: dhuber@mcw.edu.
Michael A McCreaDepartments of Neurosurgery and Neurology, Center for Neurotrauma Research, Medical College of Wisconsin, Milwaukee, WI Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: mmccrea@mcw.edu.
Sergey TarimaDivision of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: starima@mcw.edu.
Terri A deRoon-CassiniDepartment of Surgery, Division of Trauma and Critical Care, Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: tcassini@mcw.edu.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: okonkwodo@upmc.edu.
Lindsay D NelsonDepartments of Neurosurgery and Neurology, Center for Neurotrauma Research, Medical College of Wisconsin, Milwaukee, WI Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: linelson@mcw.edu.

Funding

Clincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3M
NCATS NIH HHS UL1 TR000055
6 · The paper itself

Abstract

There are limited data directly comparing recovery across traumatic brain injury subpopulations. We compared symptom recovery profiles between patients with Glasgow Coma Scale (GCS) 13-15 traumatic brain injury (TBI) from the same region in three cohorts: (1) Participants with sport-related concussion (SRC), (2) participants evaluated and discharged from the level 1 trauma center emergency department (ED), and (3) participants who required 1 + night(s) in the inpatient unit (IP). The current analysis aggregates data from two prospective cohort studies at the same institution resulting in a combined dataset of 395 patients with TBI (224 with SRC, 95 discharged from the ED, and 75 admitted [IP]). The primary outcome measure of interest was self-reported TBI symptom duration (in days). Two multivariable Cox proportional hazards models evaluated differences in symptom recovery between groups while controlling for recovery risk factors, including age, sex, race/ethnicity, acute symptom severity, psychological disorder history, loss of consciousness, and post-traumatic amnesia. The second model included only ED and IP, due to availability of additional predictor variables in these samples (e.g., education, cause of injury, peripheral injury severity). In unadjusted models, hazards of symptom recovery were lower with increasing levels of care (IP vs. ED HR=.40, p < .001; IP vs. SRC HR=.11, p < .001, ED vs. SRC HR=.28, p < .001). Controlling for covariates, longer symptom recovery in the trauma center subsamples versus SRC persisted (IP vs. SRC HR=.26, p = .018, ED vs. SRC HR=.52, p = .021), whereas differences between ED and IP became nonsignificant (HR=.86, p = .782). Acute symptom severity (HR=0.98; p < 0.001-0.010) and psychiatric history (HR=0.27-0.36; p ≤ 0.034) were independent predictors of symptom duration in both models. The results of this study suggest that patients with TBI and GCS 13-15 seen at a level 1 trauma center vary significantly in symptom recovery and severity in comparison to those with SRC, regardless of population differences in age, sex and psychiatric history.

Indexed as

Athletic InjuriesBrain ConcussionBrain Injuries, TraumaticGlasgow Coma ScaleRecovery of FunctionAdolescentAdultCohort StudiesEmergency Service, HospitalFemaleHumansMaleMiddle AgedProspective StudiesTrauma CentersYoung AdultEmergency departmentSport-related concussionSymptom recoveryTraumatic brain injury

Identifiers

PMID40532286
PMCPMC12291057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.