Evidence map›Paper›PMID 40532217›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

A New Generation of Clinical Endpoints for Critical Care Trials.

Patrick G Lyons, Anna Heath, Patrick R Lawler

Abstract readEditorialComment
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Optimizing endpoints in early phase clinical trials of acute respiratory distress syndrome.American journal of respiratory and critical care medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Patrick G LyonsDivision of Pulmonary, Allergy, and Critical Care Medicine Oregon Health & Science University Portland, Oregon.ORCID 0000-0002-1557-2787
Anna HeathChild Health Evaluative Sciences Hospital for Sick Children Toronto, Ontario, Canada.
Patrick R LawlerDepartment of Medicine University of Toronto Toronto, Ontario, Canada.

Funding

SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and TechnologyK08CA270383 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrick G Lyons · 2024 to 2026
$851k
NCI NIH HHS K08 CA270383NIH HHS K08CA270383
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40532217
PMCPMC12369439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.