Evidence map›Paper›PMID 40532067›Full record

SynthesisUnited European gastroenterology journal2025

Dietary Sugar and Sweetened Beverage Intake Increases Inflammatory Bowel Disease Risk: A Systematic Review and Meta-Analysis.

Isha Maniyar, Arpita Jajoo, Gala Godoy Brewer, Preetha Iyengar, Andrew Nguyen, Christina Fasulo, Jacob White, Alyssa Parian, Berkeley N Limketkai

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isha ManiyarDepartment of Medicine, UCSF School of Medicine, San Francisco, California, USA.ORCID https://orcid.org/0009-0007-1408-1920
Arpita JajooDivision of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-0430-694X
Gala Godoy BrewerDepartment of Medicine, University of Miami School of Medicine, Miami, Florida, USA.
Preetha IyengarDivision of Digestive Diseases, UCLA School of Medicine, Los Angeles, California, USA.
Andrew NguyenDivision of Digestive Diseases, UCLA School of Medicine, Los Angeles, California, USA.
Christina FasuloDivision of Digestive Diseases, UCLA School of Medicine, Los Angeles, California, USA.
Jacob WhiteWelch Library, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-3557-3568
Alyssa ParianDivision of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Berkeley N LimketkaiDivision of Digestive Diseases, UCLA School of Medicine, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe impact of dietary sugar intake on the risk of developing inflammatory bowel disease is unclear, with inconsistent findings across studies. The aim of this systematic review and meta-analysis was to clarify how sugar consumption contributes to the risk of developing inflammatory bowel disease (IBD) using the most recently available data.

methodsA library informationist retrieved relevant articles from PubMed, EMBASE, CINAHL, Cochrane Central, Web of Science, and Scopus. Two independent reviewers screened the abstracts and full texts, yielding 45 studies for inclusion. Meta-analyses estimated odd ratios using random effect models.

results11 prospective and 34 retrospective studies reported data on sugar intake and IBD risk. Pooled analysis showed that added sugar intake was associated with increased risk of Crohn's disease (OR 1.66; 95% Cl 1.21-2.29; n = 523,730; 14 studies) and ulcerative colitis (OR 1.59; 95% CI 1.25-2.02; n = 787,228; 18 studies). Similarly, soda/sweetened beverage intake was associated with increased risk of Crohn's disease (OR 1.58; 95% CI 1.18-2.12; n = 328,716; 12 studies) and ulcerative colitis (OR 1.72; 95% CI 1.23-2.391; n = 328,642; 13 studies).

conclusionsSugar and soda/sweetened beverage intake were associated with an increased risk of developing both Crohn's disease and ulcerative colitis. Although additional prospective investigation is warranted, current data suggest that reduction of sugar consumption might help reduce the risk of inflammatory bowel disease.

Indexed as

Carbonated BeveragesColitis, UlcerativeCrohn DiseaseDietary SugarsInflammatory Bowel DiseasesSugar-Sweetened BeveragesHumansRisk AssessmentRisk FactorsDietary Sugarsadded sugarCrohn's diseaseinflammatory bowel diseasemeta‐analysissodasoft drinkssugar intakesugar‐sweetened beveragessweetened beveragesulcerative colitis

Identifiers

PMID40532067
PMCPMC12529010

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.