Evidence map›Paper›PMID 40532050›Full record

ArticleJournal of medicinal chemistry2025

Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT

Alexandra Sink, Eline Pottie, Samuel J Carter, Robert J Tombari, Verena Weber, Paolo Carloni, Giulia Rossetti, David E Olson, Christophe P Stove, Michael Decker

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandra SinkInstitut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany.ORCID 0000-0002-7241-6182
Eline PottieLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.ORCID 0000-0002-9077-4055
Samuel J CarterDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Robert J TombariChemistry and Chemical Biology Graduate Program, University of California, Davis, Davis, California 95616, United States.ORCID 0000-0002-6561-8181
Verena WeberInstitute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.
Paolo CarloniInstitute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.ORCID 0000-0002-9010-0149
Giulia RossettiInstitute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.ORCID 0000-0002-2032-4630
David E OlsonDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-4517-0543
Christophe P StoveLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.ORCID 0000-0001-7126-348X
Michael DeckerInstitut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany.ORCID 0000-0002-6773-6245

Funding

Supplement: Chemical and Molecular Tools for Modulating GPCR FunctionR35GM148182 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI David E Olson · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM148182
6 · The paper itself

Abstract

The serotonin 2A receptor (5-HT

Indexed as

beta-ArrestinsDrug DesignGTP-Binding Protein alpha Subunits, Gq-G11LightReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor AgonistsTryptaminesHEK293 CellsHumansLigandsbeta-ArrestinsGTP-Binding Protein alpha Subunits, Gq-G11LigandsReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor AgoniststryptamineTryptamines

Identifiers

PMID40532050
PMCPMC12279067

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.