ArticleACS nano2025
Programmable Host-Guest Recognition for Shape-Shifting Supramolecular Nanostructure States.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- γ-Ray Regulated Host-Guest Molecular Recognition.Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The ability to design nanostructures with programmable and reversible morphological transformations is essential for advancing supramolecular chemistry toward functional biomaterials. Here, a pH-sensitive supramolecular system is shown comprising a peptide amphiphile functionalized with carboxylate-terminated bicyclo[2.2.2]octane (BO) guest molecules along with a cucurbit[7]uril (CB[7]) host modified with a pendant PEG chain. This system enables dynamic transitions among three nanostructure states: filamentous nanofibers, spherical micelles, and nanoscale aggregates. These transitions are governed by pH-dependent CB[7]-BO complexation, which modulates the hydrophilic-lipophilic balance and steric repulsion of the self-assembling units. The nanostructure transformations are reversible, allowing control over nanostructure states by adjusting pH and component mixing ratio. Furthermore, these transitions can be triggered autonomously using an enzymatic pH control mechanism, enabling transient morphological changes. This work highlights the potential of integrating multiple supramolecular motifs to create dynamic, programmable, and switchable nanomaterials with life-like structural transience.
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Registered trials
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