Evidence map›Paper›PMID 40532042›Full record

ArticleArchives of endocrinology and metabolism2025

Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.

Sara Moreira Anunciação, Renata de Oliveira Campos, Fabyan Esberard de Lima Beltrão, Déborah Araújo Morais, Wellington Sousa Tavares de, Fernando Barbosa, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fabio Hecht, Helton Estrela Ramos

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Article in Archives of endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Sara Moreira AnunciaçãoDepartamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.ORCID 0000-0002-8080-4900
Renata de Oliveira CamposDepartamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.ORCID 0000-0002-2888-4798
Fabyan Esberard de Lima BeltrãoHospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.ORCID 0000-0001-9713-2584
Déborah Araújo MoraisDepartamento de Análises Clínicas, Toxicologia e Ciências dos Alimentos, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.ORCID 0000-0003-2390-956X
Wellington Sousa Tavares deDepartamento de Análises Clínicas, Toxicologia e Ciências dos Alimentos, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.ORCID 0000-0001-8901-3219
Fernando BarbosaDepartamento de Análises Clínicas, Toxicologia e Ciências dos Alimentos, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.ORCID 0000-0002-2501-958X
Jéssica Fernanda CassemiroDepartamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.ORCID 0000-0002-3119-769X
Pedro Resende Ferreira RendeDepartamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.ORCID 0000-0001-8999-8871
Fabio HechtDepartment of Biomedical Genetics, University of Rochester, NY, USA.ORCID 0000-0001-9110-2587
Helton Estrela RamosDepartamento de Biorregulação, Instituto de Saúde e Ciências, Universidade Federal da Bahia, Salvador, BA, Brasil.ORCID 0000-0002-2900-2099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. SUBJECTS AND

methodsA prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.

resultsNTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).

conclusionThe association between low USC and NTIS was evident in this cohort.

Indexed as

COVID-19Euthyroid Sick SyndromesSeleniumAdultAgedBiomarkersFemaleHospitalizationHumansMaleMiddle AgedProspective StudiesSARS-CoV-2BiomarkersSeleniumCOVID-19Seleniumthyroid, nonthyroidal illness syndrome

Identifiers

PMID40532042
PMCPMC12176277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.