Evidence map›Paper›PMID 40532011›Full record

ArticleScience advances2025

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5.

Man Zhao, Dalin Zhang, Haowen Jiang, Nishanth Kuganesan, Suchitra Natarajan, Leighton Pu, Kaushik N Thakkar, Hongjuan Zhao, Quynh Thu Le, Amato J Giaccia and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Beyond mBiomedicines · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Man ZhaoDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9013-1498
Dalin ZhangDepartment of Urology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6553-7373
Haowen JiangDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4021-3820
Nishanth KuganesanDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Suchitra NatarajanDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0004-8774-8763
Leighton PuDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
Kaushik N ThakkarDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4900-3371
Hongjuan ZhaoDepartment of Urology, Stanford University, Stanford, CA 94305, USA.
Quynh Thu LeDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3682-1439
Amato J GiacciaDepartment of Oncology, University of Oxford, Oxford, UK.ORCID 0000-0002-1940-2750
James D BrooksDepartment of Urology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4521-7505
Donna M PeehlDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Jiangbin YeDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1117-4869
Erinn B RankinDepartment of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2045-2296

Funding

Translational Biology CoreP01CA257907 · NCI · STANFORD UNIVERSITY · PI Quynh-Thu Xuan Le · 2022 to 2026
$12.0M
The role of the RNA demethylase FTO in metabolic reprogramming of renal cell carcinomaR01CA272432 · NCI · STANFORD UNIVERSITY · PI Erinn B Rankin · 2023 to 2026
$1.8M
NCI NIH HHS P01 CA257907NCI NIH HHS R01 CA272432
6 · The paper itself

Abstract

Glutamine reprogramming plays a crucial role in the growth and survival of clear cell renal cell carcinoma (ccRCC), although the mechanisms governing its regulation are still not fully understood. We demonstrate that the RNA demethylase fat mass and obesity-associated gene (FTO) drives glutamine reprogramming to support ccRCC growth and survival. Genetic and pharmacologic inhibition of FTO in ccRCC cells impaired glutamine-derived reductive carboxylation, depleted pyrimidines, and increased reactive oxygen species. This led to increased DNA damage and reduced survival, which could be rescued by pyrimidine nucleobases or the antioxidant

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOAmino Acid Transport System ASCCarcinoma, Renal CellGlutamineKidney NeoplasmsMinor Histocompatibility AntigensAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceReactive Oxygen SpeciesAlpha-Ketoglutarate-Dependent Dioxygenase FTOAmino Acid Transport System ASCFTO protein, humanGlutamineMinor Histocompatibility AntigensReactive Oxygen SpeciesSLC1A5 protein, human

Identifiers

PMID40532011
PMCPMC12175902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.