Evidence map›Paper›PMID 40532000›Full record

ArticleScience advances2025

Plexin/Semaphorin antagonism orchestrates collective cell migration and organ sculpting by regulating epithelial-mesenchymal balance.

Maik C Bischoff, Jenevieve E Norton, Sarah E Clark, Mark Peifer

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Maik C BischoffDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.ORCID 0000-0002-6995-8159
Jenevieve E NortonDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.ORCID 0009-0001-1017-7323
Sarah E ClarkDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.ORCID 0009-0001-4478-8202
Mark PeiferDepartment of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.ORCID 0000-0003-1412-3987

Funding

Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesisR35GM118096 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark A. Peifer · 2016 to 2026
$6.5M
NIGMS NIH HHS R35 GM118096
6 · The paper itself

Abstract

Cell behavior emerges from the intracellular distribution of properties such as protrusion, contractility, and adhesion. Thus, characteristic emergent rules of collective migration can arise from cell-cell contacts locally tweaking architecture, orchestrating self-regulation during development, wound healing, and cancer progression. The

Indexed as

Cell MovementDrosophila ProteinsEpithelial-Mesenchymal TransitionNerve Tissue ProteinsReceptors, Cell SurfaceSemaphorinsAnimalsCadherinsDrosophila melanogasterMaleMesodermMorphogenesisTestisCadherinsDrosophila ProteinsNerve Tissue ProteinsplexA protein, DrosophilaReceptors, Cell SurfaceSemaphorins

Identifiers

PMID40532000
PMCPMC12175886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.