ArticlePloS one2025
Impact of serum phosphate levels during CRRT on extubation failure and hospital mortality in mechanically ventilated ICU patients-A study based on the MIMIC-IV database.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundElectrolyte imbalances, particularly phosphate depletion, are prevalent yet often underestimated complications in the Intensive Care Unit (ICU), notably among patients undergoing Continuous Renal Replacement Therapy (CRRT). Therefore, this study aims to examine the impact of serum phosphate levels during CRRT on the incidence of extubation failure and hospital mortality in mechanically ventilated patients.
methodsPatients subjected to both CRRT and mechanical ventilation were extracted from the MIMIC-IV database. Cox regression analysis was employed to identify the potential risk factors for the extubation failure and hospital mortality rates. Patients were categorized into three groups based on their minimum serum phosphate level (Phosphate_min) during CRRT. Kaplan-Meier survival analysis and Receiver Operating Characteristic (ROC) curves were employed to assess differences in the primary outcomes among these groups. Additionally, a restricted cubic spline curve was utilized to explore potential nonlinear relationships between Phosphate_min and the primary outcomes.
resultsThe analysis included 816 ICU patients undergoing CRRT and mechanical ventilation. Cox regression analysis identified Phosphate_min as a significant risk factor for both extubation failure (HR 1.29; 95% CI 1.22-1.36, p < 0.001) and hospital mortality (HR 1.48; 95% CI 1.37-1.60, p < 0.001). ROC curve analysis indicated that a Phosphate_min > 4.5 mg/dL was a moderate predictor for both extubation failure and hospital mortality. Kaplan-Meier analysis revealed significantly higher risks of the primary outcomes in the group with Phosphate_min > 4.5 mg/dL compared to the lower phosphate groups (log-rank p < 0.001). Additionally, restricted cubic spline analysis showed a J-shaped relationship between Phosphate_min and both primary outcomes, with nadirs at approximately 1.60 mg/dL for extubation failure and 1.98 mg/dL for hospital mortality.
conclusionPhosphate_min emerges as an independent risk factor for both extubation failure and hospital mortality. Maintaining serum phosphate levels within a therapeutic range may potentially mitigate these risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.