ArticlePloS one2025
Antenatal identification of early- and late-onset fetal growth restriction and the possible impact of the introduction of cerebroplacental ratio: Effect on perinatal and childhood outcome.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A multiparameter model combining ultrasound and maternal serum biomarkers accurately predicts late-onset fetal growth restriction.American journal of translational research · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of antenatal identification of small for gestational age (SGA) fetuses on perinatal and childhood outcomes, separately analyzing early- and late-onset fetal growth restriction (FGR). MATERIALS AND
methodsA register-based cohort study of all newborns born SGA, delivered in Stockholm in 2014 and 2017, n = 5499. Ultrasound reports of fetuses born SGA were reviewed and fetuses identified as SGA with ultrasound before birth were further defined as early- or late-onset FGR according to established criteria. Data from the medical chart for maternity and delivery was linked to nationwide Swedish registers. Adverse outcomes for antenatally non-identified SGA/FGR newborns and fetuses identified as early- or late-onset FGR were compared using logistic regression models. A composite outcome, severe adverse outcome, was constructed and defined as at least one of the following: stillbirth, severe newborn distress, severe neonatal outcome, severe childhood outcome. Individual components of the composite outcome were analyzed as secondary outcomes.
resultsIdentified early-onset FGR fetuses had an increased risk for severe adverse outcome, compared to non-identified SGA/FGR (aOR 1.81, 95% CI 1.25-2.61), in contrast to late-onset FGR fetuses (aOR 1.14, 95% CI 0.78-1.67). Identified early-onset FGR had a decreased risk of stillbirth (aOR 0.47, 95% CI 0.23-0.96), an increased risk of severe newborn distress (aOR 2.80, 95% CI 1.79-4.39) and severe childhood outcome (aOR 3.00, 95% CI 1.51-5.94), compared to non-identified SGA/FGR. Identified late-onset FGR was only associated with an increased risk of severe childhood outcome (aOR 1.91, 95% CI 1.04-3.52).
conclusionIdentified early-onset FGR fetuses benefited from identification with a decreased risk of stillbirth at the price of an increased risk for severe newborn and childhood outcomes. For late-onset FGR the advantages were undetectable; identification was associated with an increased risk for severe childhood outcome, while the negative association with stillbirth did not reach significance.
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