ArticleProceedings of the National Academy of Sciences of the United States of America2025
Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Genomic Signatures of Selection Are Enriched in Differentially Expressed Genes in Sticklebacks Adapting to Contrasting Environments.Genome biology and evolution · 2026Article
- Natural genetic variation in calcium sensor genes as a novel resource for abiotic stress tolerance in crops.Frontiers in plant science · 2026Review
- Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microbial solutions to dietary stress: experimental evolution reveals host-microbiome interplay inProceedings. Biological sciences · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Evolutionary adaptation to new environments likely results from a combination of selective sweeps and polygenic shifts, depending on the genetic architecture of traits under selection. While selective sweeps have been widely studied, polygenic responses are thought to be more prevalent but remain challenging to quantify. The infinitesimal model makes explicit the hypothesis about the dynamics of changes in allele frequencies under selection, where only allelic effect sizes, frequencies, linkage, and gametic disequilibrium matter. Departures from this, like long-range correlations of allele frequency changes, could be a signal of epistasis in polygenic response. We performed an Evolve & Resequence experiment in
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