Evidence map›Paper›PMID 40531753›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2025

Protective effects of Aloe vera extract against doxorubicin-induced degeneration in ovarian follicles and stromal cells in mice.

E I T de Assis, A N Godinho, J M O Freire, M F de Lima Neto, J J N Costa, A L P Souza, A P O do Monte, M H T Matos, A L M de Sousa, J R V Silva and 1 more

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Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E I T de AssisLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0001-8164-3937
A N GodinhoNúcleo de Pesquisa em Experimentação Animal, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0003-3410-2315
J M O FreireNúcleo de Pesquisa em Experimentação Animal, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0002-3412-8964
M F de Lima NetoLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0003-0034-0606
J J N CostaLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0003-3578-5664
A L P SouzaLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0002-0348-4026
A P O do MonteNúcleo de Biotecnologia Aplicada ao Desenvolvimento do Folículo Ovariano, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brasil.ORCID http://orcid.org/0000-0001-9945-4552
M H T MatosNúcleo de Biotecnologia Aplicada ao Desenvolvimento do Folículo Ovariano, Universidade Federal do Vale do São Francisco, Petrolina, PE, Brasil.ORCID http://orcid.org/0000-0001-6215-5292
A L M de SousaEmbrapa Caprinos e Ovinos, Fazenda Três Lagoas, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0002-4733-5102
J R V SilvaLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0002-5970-6177
A W B SilvaLaboratório de Biotecnologia e Fisiologia da Reprodução, Universidade Federal do Ceará, Sobral, CE, Brasil.ORCID http://orcid.org/0000-0003-4105-426X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to evaluate the protective effects of Aloe vera on doxorubicin (DOX)-induced degeneration in ovarian follicles and stromal cells in mice. Mice (n=48) were randomly divided into six groups. The positive control group mice received pretreatment of N-acetylcysteine orally (po), followed by a single intraperitoneal (ip) dose of DOX after 1 h (NAC+DOX). The negative control group mice were pre-treated with saline (po) and administered a single DOX dose (ip) after 1 h (SAL+DOX). The other groups of mice were pre-treated with different concentrations (0.1, 1.0, or 10.0 mg/kg; po) of Aloe vera and then received a single dose of DOX (ip) after 1 h (AV0.1+DOX, AV1.0+DOX, and AV10.0+DOX). The control group received saline po and ip (SAL+SAL). Aloe vera was administered once daily for 3 consecutive days. On the fourth day, the ovaries were processed for histological analysis, immunohistochemistry, and real-time PCR (mRNA for superoxide dismutase (SOD), catalase (CAT), nuclear factor erythroid 2-related factor 2 (NRF2), and tumor necrosis factor-α (TNF-α). Results showed that 0.1 and 1.0 mg/kg Aloe vera protected ovarian follicles and stromal density against DOX-induced degeneration. Furthermore, 0.1 and 1.0 mg/kg Aloe vera reduced TNF-α protein expression and increased NRF2, SOD, and CAT mRNA levels. In conclusion, 0.1 and 1.0 mg/kg Aloe vera had protective effects against DOX-induced degeneration in ovarian follicles and stromal cells in mice.

Indexed as

AloeDoxorubicinOvarian FolliclePlant ExtractsStromal CellsAnimalsAntibiotics, AntineoplasticFemaleMiceRandom AllocationSuperoxide DismutaseAntibiotics, AntineoplasticDoxorubicinPlant ExtractsSuperoxide Dismutase

Identifiers

PMID40531753
PMCPMC12172158

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.