Evidence map›Paper›PMID 40531666›Full record

ArticleGigaScience2025

The telomere-to-telomere gapless genome of grass carp provides insights for genetic improvement.

Fei Liu, Yuan Li, Guishuang Wang, Dong Zhang, Xinlan Yang, Chaowei Zhou, Rongzhu Zhou, Haiping Liu

Erratum issuedAbstract read
In one paragraph

Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Fei LiuSchool of Ecology and Environment, Tibet University, Lhasa, Tibet 850000, China.ORCID 0009-0004-8000-5596
Yuan LiWuhan Huabiology Co., Ltd., Wuhan, Hubei 430000, China.ORCID 0000-0002-4802-0305
Guishuang WangInstitute of Aquatic Sciences, Tibet Autonomous Region Academy of Agricultural and Animal Husbandry Sciences, Lhasa, Tibet 850000, China.
Dong ZhangSchool of Ecology and Environment, Tibet University, Lhasa, Tibet 850000, China.
Xinlan YangInstitute of Aquatic Sciences, Tibet Autonomous Region Academy of Agricultural and Animal Husbandry Sciences, Lhasa, Tibet 850000, China.
Chaowei ZhouInstitute of Aquatic Sciences, Tibet Autonomous Region Academy of Agricultural and Animal Husbandry Sciences, Lhasa, Tibet 850000, China.
Rongzhu ZhouNational Animal Husbandry Services, Beijing 100125, China.ORCID 0009-0003-6934-8224
Haiping LiuSchool of Ecology and Environment, Tibet University, Lhasa, Tibet 850000, China.ORCID 0000-0002-6280-0850

Funding

Guangzhou Key R&D Program 2024B03J1082National Natural Science Foundation of China U23A20249
6 · The paper itself

Abstract

backgroundThe grass carp (Ctenopharyngodon idella) is a large herbivorous freshwater fish belonging to the Cyprinidae family. It is widely cultivated as a food source in China and is renowned as one of the Four Great Domestic Fishes. Despite its economic importance, the published genome assemblies of grass carp remain incomplete due to gaps, thereby hindering molecular research and genetic improvement.

resultsIn this study, we report the assembly of a telomere-to-telomere (T2T) gap-free genome of the grass carp with total length of 890,918,310 bp for 24 chromosomes without gaps, representing the highest completeness and assembly quality to date. Our assembly contains 27,446 protein-coding genes, and 93.04% of all were annotated with multiple databases, with 48 telomeres and 24 centromeres characterized. Gap-free reference genomes enable us to study the structure of centromeres and identify conserved centromere-specific satellite motifs for grass carp. Furthermore, we identified 108 gene-related gaps across 12 chromosomes and 38 structural variations across 17 chromosomes in this T2T assembly.

conclusionsThe validated gap-free genome provides invaluable resource for future genomic studies grass carp, offering new insights into its genetic architecture and evolutionary dynamics.

Indexed as

CarpsGenomeTelomereAnimalsCentromereChromosomesGenomicsMolecular Sequence Annotationgrass carpphylogenomictelomere-to-telomere genome

Identifiers

PMID40531666
PMCPMC12204074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.