Evidence map›Paper›PMID 40531660›Full record

ArticleEuropean journal of immunology2025

IL-4, IL-15, and Type I Interferon Orchestrate the Shaping of the Heterogeneity of Virtual Memory CD8 T Cells.

Hi Jung Park, Sung Min Choi, Eun A Choi, Hyun Ji Boo, Jae Il Lee, Kyeong Cheon Jung

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hi Jung ParkGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Sung Min ChoiGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Eun A ChoiGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hyun Ji BooGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jae Il LeeGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kyeong Cheon JungGraduate Course of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of virtual memory CD8 T cells is dependent on IL-4, type I interferon, and IL-15. However, it remains unclear whether these cytokines individually contribute to the generation of specific subsets of virtual memory CD8 T cells. In this study, virtual memory CD8 T cells were categorized into four subsets based on Ly6C and Sca-1 expression, and their development was examined using knock-out mice lacking IFNAR1, IL-4, or IL-15Rα. Notably, both Ly6C

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryInterferon Type IInterleukin-15Interleukin-4Memory T CellsAnimalsAntigens, LyMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaAntigens, LyIfnar1 protein, mouseInterferon Type IInterleukin-15Interleukin-4Receptor, Interferon alpha-betaIL‐15IL‐4RNA sequencingtype I interferonvirtual memory CD8 T cells

Identifiers

PMID40531660
PMCPMC12176074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.