Evidence map›Paper›PMID 40531624›Full record

ArticleCell reports2025

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice.

Steffy B Manjila, Seoyoung Son, Deniz Parmaksiz, Hannah Kline, Rebecca Betty, Yuan-Ting Wu, Hyun-Jae Pi, Donghui Shin, Josephine K Liwang, Fae N Kronman and 5 more

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Steffy B ManjilaDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Seoyoung SonDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Deniz ParmaksizDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Hannah KlineDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Rebecca BettyDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Yuan-Ting WuDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Hyun-Jae PiDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Donghui ShinDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Josephine K LiwangDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Fae N KronmanDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Ingvild E BjerkeDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Kyle McGovernCollege of Information Science and Technology, The Pennsylvania State University, University Park, PA, USA.
Justin SilvermanCollege of Information Science and Technology, The Pennsylvania State University, University Park, PA, USA.
Anirban PaulDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Yongsoo KimDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA. Electronic address: yuk17@psu.edu.

Funding

A Confocal Fluorescence Microscopy Brain Data ArchiveR24MH114793 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI ALEXANDER J ROPELEWSKI, Alan Michael Watson · 2017 to 2026
$10.1M
Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse BrainsRF1MH124605 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GEE, JAMES C, KIM, YONGSOO · 2020 to 2020
$3.8M
Brain-wide input and output wiring diagram of oxytocin neurons and its function in claustrum-endopiriform complexR01MH116176 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KIM, YONGSOO · 2018 to 2022
$2.4M
Medical Scientist Training ProgramT32GM149380 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERT LEVENSON · 2023 to 2026
$2.3M
Cross-Disciplinary Neural Engineering (CDNE) Training ProgramT32NS115667 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI GLUCKMAN, BRUCE J · 2021 to 2025
$1.1M
Neuroanatomy and function of the ventral claustrum-dorsal endopiriform nucleus in miceR01NS136371 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Yongsoo Kim · 2025 to 2026
$1.0M
NIGMS NIH HHS T32 GM149380NIMH NIH HHS R01 MH116176NIMH NIH HHS R24 MH114793NIMH NIH HHS RF1 MH124605NINDS NIH HHS R01 NS136371NINDS NIH HHS T32 NS115667
6 · The paper itself

Abstract

The dorsal endopiriform nucleus (EPd) is a cortical subplate structure within the piriform cortex that shares similar developmental origins to those of the claustrum. Although implicated in epilepsy and olfaction, the EPd's connectivity and function remain largely unclear due to the lack of specific molecular markers. Our recent mapping study identifies the oxytocin receptor (Oxtr) as highly enriched in the EPd. Immunohistochemical and spatial transcriptomic analyses confirm Oxtr enrichment and a distinct molecular profile of the EPd compared to the claustrum. Whole-brain input-output mapping of EPd-Oxtr neurons unveils extensive bidirectional connections with ventral brain regions, orchestrating circuits regulating olfaction, internal state, and emotion. Furthermore, in vivo miniscope recordings reveal that EPd-Oxtr neurons exhibit high baseline activity during exploration, with a sharp decrease in response to novel stimuli. Together, these findings suggest that EPd-Oxtr neurons integrate interoceptive and exteroceptive signals, contributing to internal state regulation and behavioral adaptation to novel environmental cues.

Indexed as

BrainPiriform CortexAnimalsMiceMice, Inbred C57BLNeuronsReceptors, OxytocinReceptors, Oxytocinbrain connectivityclaustrumCP: Neurosciencedorsal endopiriform nucleusexploratory behavioroxytocin receptorspatial transcriptomewhole-brain mapping

Identifiers

PMID40531624
PMCPMC12335281

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.