Evidence map›Paper›PMID 40531623›Full record

ArticleCell reports2025

Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8

Zhenpeng Dai, Yuqian Chang, Eunice Y Lee, Valia P Leifer, Eddy Hsi Chun Wang, Rolando Perez-Lorenzo, Annemieke de Jong, Angela M Christiano

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenpeng DaiDepartment of Dermatology, Columbia University, New York, NY, USA.
Yuqian ChangDepartment of Dermatology, Columbia University, New York, NY, USA.
Eunice Y LeeDepartment of Dermatology, Columbia University, New York, NY, USA.
Valia P LeiferDepartment of Dermatology, Columbia University, New York, NY, USA.
Eddy Hsi Chun WangDepartment of Dermatology, Columbia University, New York, NY, USA.
Rolando Perez-LorenzoDepartment of Dermatology, Columbia University, New York, NY, USA.
Annemieke de JongDepartment of Dermatology, Columbia University, New York, NY, USA.
Angela M ChristianoDepartment of Dermatology, Columbia University, New York, NY, USA; Department of Genetics and Development, Columbia University, New York, NY, USA. Electronic address: amc65@cumc.columbia.edu.

Funding

Project 1: Translational Science of Alopecia AreataP50AR070588 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FLORATOS, ARIS · 2016 to 2021
$8.0M
Targeting the NKG2A Pathway in Alopecia AreataR01AR084005 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Angela M Christiano · 2024 to 2026
$1.7M
Functional Studies of the IL-7/IL-7R Pathway in Alopecia AreataK01AR070291 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAI, ZHENPENG · 2017 to 2022
$693k
Five-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361k
Investigating the role of JAK/STAT3 signaling in the hair cycleF31AR077409 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, YOO JIN · 2020 to 2021
$80k
NIAMS NIH HHS F31 AR077409NIAMS NIH HHS K01 AR070291NIAMS NIH HHS P50 AR070588NIAMS NIH HHS R01 AR084005NIH HHS S10 OD030282
6 · The paper itself

Abstract

Alopecia areata (AA) is an immune-mediated hair loss disorder characterized by the infiltration of immune cells, including clonally expanded CD8

Indexed as

Alopecia AreataCD8-Positive T-LymphocytesSingle-Cell AnalysisAnimalsClone CellsDisease Models, AnimalMiceMice, Inbred C3HReceptors, Antigen, T-CellReceptors, Antigen, T-Cellalopecia areataautoimmune diseaseclonal T cell expansionCP: Immunologyhair folliclepathogenic CD8(+) T cellstargeted T cell depletionTCR retrogenic mice

Identifiers

PMID40531623
PMCPMC12854772

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.