Evidence map›Paper›PMID 40531611›Full record

ArticleDrug delivery2025

Targeted treatment of hepatocellular carcinoma with aptamer-guided solid lipid nanoparticles loaded with norcantharidin.

Yilin Xu, Min Wang, Jing Wu, Manshu Zou, Donghai Wu, Jing Gong, Pingjie Wang, Hong Yan, Xinhua Xia

Abstract read
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yilin XuSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Min WangThe Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.
Jing WuSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Manshu ZouSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Donghai WuSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Jing GongSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Pingjie WangSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Hong YanSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Xinhua XiaSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer is a common malignancy in the world, and its incidence and mortality rate are increasing year by year. The disease has a short course and a high mortality rate, posing a serious threat to humanity and health. The objective of this study is to create novel liver-targeted nanoparticles as a potential treatment for liver cancer. The aptamer (APS613-1) modified redox-sensitive norcantharidin solid lipid nanoparticles (Apt-PEG

Indexed as

Antineoplastic AgentsAptamers, NucleotideBridged Bicyclo Compounds, HeterocyclicCarcinoma, HepatocellularLipidsLiver NeoplasmsNanoparticlesAnimalsApoptosisCell Line, TumorCell ProliferationDrug CarriersDrug Delivery SystemsHep G2 CellsHumansMaleAntineoplastic AgentsAptamers, NucleotideBridged Bicyclo Compounds, HeterocyclicDrug CarriersLipidsnorcantharidinPolyethylene Glycolsaptamerhepatocellular carcinomananoparticlesNorcantharidintargeted drug delivery system

Identifiers

PMID40531611
PMCPMC12180343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.