ArticleMethods in molecular biology (Clifton, N.J.)2025
A Novel Tyrosine Hyperoxidation Enables Selective Peptide Cleavage.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Site-selective cleavage of amide bonds in peptide and protein constitutes a valuable modification that has found a wide spectrum of applications in proteomics, chemical biology, and drug development. Here we describe a novel tyrosine-selective peptide cleavage method enabled by Dess-Martin periodinane. This reaction leads to the breakdown of the N-terminal amide bond of tyrosine, generating a C-terminal peptide fragment bearing an unusual hyperoxidized tyrosine motif, 4,5,6,7-tetraoxo-1H-indole-2-carboxamide, along with an intact N-terminal peptide fragment. Application of this methodology to the sequencing of a few cyclic peptides containing tyrosine residues has been readily achieved.
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