Evidence map›Paper›PMID 40531448›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous Flow.

Junqi Su, Jiannan Zhao

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Junqi SuCollege of Science, Shenyang University of Chemical Technology, Shenyang, People's Republic of China.
Jiannan ZhaoSchool of Chemistry, Dalian University of Technology, Dalian, People's Republic of China. jnzhao@dlut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides are ubiquitous structural units in many therapeutic agents, agrochemicals, and organic materials. However, synthesizing these structures from amino acids typically results in considerable waste, which has led the American Chemical Society (ACS) Green Chemistry Institute (GCI) Pharmaceutical Roundtable to list "general methods for catalytic amide or peptide formation" as a highly desirable areas for sustainable synthetic method development. Here, we present a photocatalytic oxidation-reduction condensation process that involves successive single-electron oxidation of phosphine for the catalytic formation of acyloxyphosphonium ions in the presence of a stoichiometric or catalytic amount of triphenylphosphine (PPh

Indexed as

AmidesOrganophosphorus CompoundsPeptidesCatalysisOxidation-ReductionPhosphinesPhotochemical ProcessesSolid-Phase Synthesis TechniquesAmidesOrganophosphorus CompoundsPeptidesPhosphinesAcyloxyphosphonium ionsContinuous flowOxidation–reduction condensationPeptidesPhotocatalysisSolid-phase peptide synthesis (SPPS)

Identifiers

PMID40531448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.